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Perospirone hydrochloride tablets
Perospirone is an atypical antipsychotic that blocks dopamine D2 receptors and serotonin 5-HT2A receptors in the brain.
Perospirone is an atypical antipsychotic that blocks dopamine D2 receptors and serotonin 5-HT2A receptors in the brain. Used for Schizophrenia, Acute agitation in psychotic disorders.
At a glance
| Generic name | Perospirone hydrochloride tablets |
|---|---|
| Sponsor | Shanghai Mental Health Center |
| Drug class | Atypical antipsychotic |
| Target | Dopamine D2 receptor; Serotonin 5-HT2A receptor |
| Modality | Small molecule |
| Therapeutic area | Psychiatry/Neurology |
| Phase | FDA-approved |
Mechanism of action
Perospirone hydrochloride acts as a dopamine D2 receptor antagonist and serotonin 5-HT2A receptor antagonist, which are the primary mechanisms underlying its antipsychotic effects. By blocking these receptors, it reduces dopaminergic and serotonergic hyperactivity implicated in psychotic symptoms. This dual antagonism is characteristic of atypical antipsychotics and is associated with a lower risk of extrapyramidal side effects compared to typical antipsychotics.
Approved indications
- Schizophrenia
- Acute agitation in psychotic disorders
Common side effects
- Extrapyramidal symptoms
- Sedation
- Weight gain
- Prolactin elevation
- Akathisia
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |