{"id":"perospirone-hydrochloride-tablets","safety":{"commonSideEffects":[{"rate":null,"effect":"Extrapyramidal symptoms"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Prolactin elevation"},{"rate":null,"effect":"Akathisia"}]},"_chembl":{"chemblId":"CHEMBL1472975","moleculeType":"Small molecule","molecularWeight":"426.59"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Perospirone hydrochloride acts as a dopamine D2 receptor antagonist and serotonin 5-HT2A receptor antagonist, which are the primary mechanisms underlying its antipsychotic effects. By blocking these receptors, it reduces dopaminergic and serotonergic hyperactivity implicated in psychotic symptoms. This dual antagonism is characteristic of atypical antipsychotics and is associated with a lower risk of extrapyramidal side effects compared to typical antipsychotics.","oneSentence":"Perospirone is an atypical antipsychotic that blocks dopamine D2 receptors and serotonin 5-HT2A receptors in the brain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:41:19.372Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Schizophrenia"},{"name":"Acute agitation in psychotic disorders"}]},"trialDetails":[{"nctId":"NCT04826510","phase":"PHASE4","title":"Efficacy and Safety of Peropirone Hydrochloride Tablets in the Treatment of Adolescent Bipolar Disorder Depression","status":"UNKNOWN","sponsor":"Shanghai Mental Health Center","startDate":"2020-11-25","conditions":"Depressive Disorder","enrollment":189}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Perospirone hydrochloride tablets","genericName":"Perospirone hydrochloride tablets","companyName":"Shanghai Mental Health Center","companyId":"shanghai-mental-health-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Perospirone hydrochloride tablets are a small molecule used to treat depressive disorder. They are available in tablet form and have been studied in clinical trials for their efficacy and safety in treating adolescent bipolar disorder depression.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}