Shanghai Mental Health Center

Quick facts

Marketed products

• amisulpride with Clozapine
• Donepezil and Lithium · Neurology/Psychiatry
  Donepezil inhibits acetylcholinesterase to increase acetylcholine levels in the brain, while lithium modulates intracellular signaling pathways and neuroprotection.
• fluoxetine + Amfebutamone · Psychiatry / Mental Health
  This combination enhances monoamine neurotransmission by inhibiting serotonin reuptake (fluoxetine) and inhibiting norepinephrine and dopamine reuptake (amfebutamone).
• Lithium carbonate + perospirone hydrochloride · Psychiatry
  Lithium carbonate modulates intracellular signaling pathways to stabilize mood, while perospirone hydrochloride acts as an atypical antipsychotic by blocking dopamine and serotonin receptors.
• Lithium Carbonate Pill · Psychiatry
  Lithium carbonate modulates intracellular signaling pathways, particularly inhibiting inositol monophosphatase and glycogen synthase kinase-3 (GSK-3), which stabilizes mood and reduces manic and depressive episodes.
• Lithium+fluvoxamine · Psychiatry
  Lithium enhances mood stabilization through effects on intracellular signaling, while fluvoxamine increases serotonin availability by inhibiting its reuptake, together targeting mood disorders through complementary neurochemical pathways.
• Mirtazapine/SNRIs · Psychiatry/Mental Health
  Mirtazapine is a tetracyclic antidepressant that blocks alpha-2 adrenergic receptors and serotonin 5-HT2 and 5-HT3 receptors, increasing norepinephrine and serotonin neurotransmission.
• Perospirone hydrochloride tablets · Psychiatry/Neurology
  Perospirone is an atypical antipsychotic that blocks dopamine D2 receptors and serotonin 5-HT2A receptors in the brain.
• Placebo plus Lithium · Psychiatry
  Lithium modulates intracellular signaling pathways, particularly inhibiting glycogen synthase kinase-3 (GSK-3) and affecting monoamine neurotransmitter systems to stabilize mood.
• placebo with Clozapine · Psychiatry
  Clozapine is an atypical antipsychotic that blocks dopamine and serotonin receptors in the brain to reduce psychotic symptoms.
• sodium valproate with Clozapine · Psychiatry
  This combination pairs sodium valproate (a histone deacetylase inhibitor and GABA enhancer) with clozapine (an atypical antipsychotic) to provide synergistic effects on mood stabilization and antipsychotic activity.
• toludesvenlafaxine hydrochloride sustained-release tablets · Psychiatry / Mental Health
  Toludesvenlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that increases synaptic levels of serotonin and norepinephrine by blocking their reuptake at the presynaptic membrane.

Phase 3 pipeline

• Anyu Peibo · Psychiatry
  Anyu Peibo is a medication used to treat depression.
• Intramuscular Haloperidol · Psychiatry
  Haloperidol is a typical antipsychotic that blocks dopamine D2 receptors in the brain to reduce psychotic symptoms and agitation.
• Octohydroaminoacridine Succinate · Neurology
  Octohydroaminoacridine succinate is a cognitive enhancer that likely increases acetylcholine levels in the brain by inhibiting acetylcholinesterase.
• Phase 1: Amisulpride · Psychiatry
  Amisulpride is a selective dopamine D2 and D3 receptor antagonist that blocks dopamine signaling in the brain to reduce psychotic symptoms and improve mood.
• Phase 1: Aripiprazole · Psychiatry
  Aripiprazole is a dopamine D2/D3 receptor partial agonist that modulates dopaminergic and serotonergic neurotransmission in the brain.
• Phase 1: Olanzapine · Psychiatry
  Olanzapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain.
• Phase 1: Perphenazine · Psychiatry
  Perphenazine is a typical antipsychotic that blocks dopamine D2 receptors in the brain to reduce psychotic symptoms.
• Phase 1: Risperidone · Psychiatry
  Risperidone is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain.
• Phase 2: Amisulpride · Psychiatry
  Amisulpride is a selective dopamine D2 and D3 receptor antagonist that blocks dopamine signaling in the brain to reduce psychotic symptoms and improve mood.
• Phase 2: Clozapine · Psychiatry
  Clozapine is an atypical antipsychotic that blocks dopamine D2 receptors and serotonin 5-HT2A receptors in the brain.
• Phase 2: Olanzapine · Psychiatry
  Olanzapine is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain.
• Phase 3B: Clozapine or another SGAs · Psychiatry
  Clozapine and other second-generation antipsychotics block dopamine and serotonin receptors in the brain to reduce psychotic symptoms and improve mood regulation.

Phase 2 pipeline

• Augment with Aripiprazole · Psychiatry / Neurology
  Aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors that modulates dopaminergic and serotonergic neurotransmission in the brain.
• Augment with Memantine · Neurology
  Augment with Memantine is a combination of a glutamate receptor antagonist and a NMDA receptor antagonist, which may help to improve cognitive function in patients with Alzheimer's disease.
• bear bile pill
• conventional mood stabilizers
• Dayingpian · Other
• Generic Escitalopram
• Innovator Escitalopram · Neurology
  Selective serotonin reuptake inhibitor
• Intramuscular Levosulpiride
• Lemborexant tablets · Neurology
  Treats insomnia by modulating orexin receptors
• Orcinoside · Other
• Xiongdan Wan
• Yuxintine · Other

Phase 1 pipeline

• Aripiprazole with Clozapine
• Drug: fluoxetine
• methadone maintenance treatment
• Risperidone with Clozapine
• Toludivenlafaxine hydrochloride sustained-release tablets
• Traditional Chinese Medicine JITAI

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Shanghai Mental Health Center portfolio CI brief
• Shanghai Mental Health Center pipeline updates RSS

Frequently asked questions about Shanghai Mental Health Center

Related

• amisulpride with Clozapine
• Donepezil and Lithium · Neurology/Psychiatry
• fluoxetine + Amfebutamone · Psychiatry / Mental Health
• Lithium carbonate + perospirone hydrochloride · Psychiatry
• Lithium Carbonate Pill · Psychiatry
• Sector hub: All tracked pharma companies