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Intramuscular Haloperidol
Haloperidol is a typical antipsychotic that blocks dopamine D2 receptors in the brain to reduce psychotic symptoms and agitation.
Haloperidol is a typical antipsychotic that blocks dopamine D2 receptors in the brain to reduce psychotic symptoms and agitation. Used for Acute agitation and psychosis, Schizophrenia, Bipolar disorder with acute mania.
At a glance
| Generic name | Intramuscular Haloperidol |
|---|---|
| Also known as | Intramuscular Haloperidol parenteral solution, Haldol |
| Sponsor | Shanghai Mental Health Center |
| Drug class | Typical antipsychotic |
| Target | Dopamine D2 receptor |
| Modality | Small molecule |
| Therapeutic area | Psychiatry |
| Phase | Phase 3 |
Mechanism of action
Haloperidol antagonizes dopamine D2 receptors in the mesolimbic and mesocortical pathways, which reduces positive symptoms of psychosis such as hallucinations and delusions. The intramuscular formulation provides rapid onset of action and is used for acute agitation or when oral administration is not feasible. It also has some activity at other dopamine receptors and possesses anticholinergic properties.
Approved indications
- Acute agitation and psychosis
- Schizophrenia
- Bipolar disorder with acute mania
Common side effects
- Extrapyramidal symptoms (dystonia, akathisia, parkinsonism)
- Sedation
- Orthostatic hypotension
- Tardive dyskinesia (with chronic use)
- Neuroleptic malignant syndrome
Key clinical trials
- Haloperidol for Pain Control in Patients With Acute Musculoskeletal Back Pain in the Emergency Department (PHASE4)
- The IM-ZBULLE Study : " Z-track " and " Airlock " Techniques During Intramuscular Injection of Haloperidol Decanoate (NA)
- A Study of Olanzapine in Patients With Acute Agitation (PHASE3)
- IM Olanzapine Versus Haloperidol or Midazolam (PHASE4)
- A Randomized, Open-Label, Multi-Center Study To Evaluate The Efficacy And Safety Of Intramuscular Ziprasidone In Patients With Agitation (PHASE3)
- Inhaled Loxapine vs Intramuscular (IM) Haloperidol + Lorazepam for Agitation (PHASE4)
- Olanzapine, Haloperidol, Ziprasidone, Midazolam for Acute Undifferentiated Agitation
- Ziprasidone vs Standard Therapy for Agitated Patients in the ED (PHASE4)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |