Last reviewed 2026-04-23 · How we verify

Zyprexa® (OLANZapine 5MG)

Zyprexa works by blocking the action of dopamine and serotonin in the brain, which helps to reduce symptoms of psychosis.

Zyprexa works by blocking the action of dopamine and serotonin in the brain, which helps to reduce symptoms of psychosis. Used for Treatment of schizophrenia, Treatment of bipolar disorder.

At a glance

Mechanism of action

Olanzapine, the active ingredient in Zyprexa, is an atypical antipsychotic that acts as a dopamine D2 and serotonin 5-HT2A receptor antagonist. This mechanism of action helps to reduce the symptoms of schizophrenia and bipolar disorder.

Approved indications

• Treatment of schizophrenia
• Treatment of bipolar disorder

Common side effects

• Weight gain
• Dizziness
• Headache
• Nausea
• Fatigue

Key clinical trials

• Food Study of Olanzapine Tablets 5 mg and Zyprexa® Tablets 5 mg (PHASE1)
• Fasting Study of Olanzapine Tablets 5 mg and Zyprexa® Tablets 5 mg (PHASE1)
• Feasibility of Olanzapine at REduced doSe in hIGHly Emetogenic chemoTherapy (PHASE3)
• Safety and Tolerability of INP105 (Olanzapine by I231 POD® Device) Nasal Spray in Healthy Volunteers - SNAP 101 (PHASE1)
• Bioequivalence Study of Torrent Pharmaceutical Ltd.'s Olanzapine Orally Disintegrating 5mg Tablets Under Fasting Condition (PHASE1)
• Bioequivalence Study of Torrent Pharmaceutical Ltd.'s Olanzapine Orally Disintegrating 5mg Tablets Under Fed Condition (PHASE1)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Zyprexa® (OLANZapine 5MG) CI brief — competitive landscape report
• Zyprexa® (OLANZapine 5MG) updates RSS · CI watch RSS
• CR-CSSS Champlain-Charles-Le Moyne portfolio CI