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Normal saline with epinephrine — Competitive Intelligence Brief
marketed
Sympathomimetic amine / Vasopressor
Alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors
Emergency Medicine / Critical Care
Small molecule
Live · refreshed every 30 min
Target snapshot
Normal saline with epinephrine (Normal saline with epinephrine) — West Penn Allegheny Health System. Epinephrine stimulates alpha and beta adrenergic receptors to increase heart rate, blood pressure, and cardiac contractility, while normal saline provides fluid volume and electrolyte balance.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Normal saline with epinephrine TARGET | Normal saline with epinephrine | West Penn Allegheny Health System | marketed | Sympathomimetic amine / Vasopressor | Alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors | |
| Low-dose epinephrine | Low-dose epinephrine | Icahn School of Medicine at Mount Sinai | marketed | Sympathomimetic amine / Catecholamine | Alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors | |
| Atropine sulfate and epinephrine | Atropine sulfate and epinephrine | Dar El Oyoun Hospital | marketed | Anticholinergic agent and sympathomimetic amine combination | Muscarinic acetylcholine receptors (atropine); alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors (epinephrine) | |
| cardiac output changes with "ephedrine" | cardiac output changes with "ephedrine" | University Tunis El Manar | marketed | Sympathomimetic amine | Alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors | |
| epinephrine perfusion | epinephrine perfusion | Central Hospital, Nancy, France | marketed | Sympathomimetic amine / Catecholamine | Alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors | |
| High-dose epinephrine | High-dose epinephrine | Icahn School of Medicine at Mount Sinai | marketed | Catecholamine; adrenergic agonist | Alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors | |
| IM epinephrine 1:1000 | IM epinephrine 1:1000 | University of Louisville | marketed | Catecholamine; adrenergic agonist | Alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors |
Recent regulatory actions (last 90 days)
- — cardiac output changes with "ephedrine" · FDA · approved · US · University Tunis El Manar
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Sympathomimetic amine / Vasopressor class)
- The University of Texas at Arlington · 1 drug in this class
- West Penn Allegheny Health System · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Normal saline with epinephrine — Competitive Intelligence Brief. https://druglandscape.com/ci/normal-saline-with-epinephrine. Accessed 2026-06-10.
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