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cardiac output changes with "ephedrine"
Ephedrine is a sympathomimetic amine that stimulates alpha and beta-adrenergic receptors to increase heart rate, blood pressure, and cardiac output.
Ephedrine is a sympathomimetic amine that stimulates alpha and beta-adrenergic receptors to increase heart rate, blood pressure, and cardiac output. Used for Hypotension and shock, Bronchospasm and asthma, Nasal congestion.
At a glance
| Generic name | cardiac output changes with "ephedrine" |
|---|---|
| Also known as | cardiac output: CO (cm3 / min) = ITV * S * HR . ITV (cm) = integral time velocity is measured by pulsed doppler at the level of the ascending aorta, on apical cut. |
| Sponsor | University Tunis El Manar |
| Drug class | Sympathomimetic amine |
| Target | Alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Ephedrine acts as a direct and indirect adrenergic agonist, binding to alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors. This stimulation increases myocardial contractility and heart rate, leading to increased cardiac output. It also causes peripheral vasoconstriction through alpha-adrenergic effects, which elevates systemic vascular resistance and blood pressure.
Approved indications
- Hypotension and shock
- Bronchospasm and asthma
- Nasal congestion
Common side effects
- Tachycardia
- Hypertension
- Tremor
- Anxiety
- Insomnia
- Palpitations
Key clinical trials
- Changes in Cardiac Output During Cesarean Delivery Under Spinal Anesthesia
- Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia (PHASE4)
- Ninvasive Cardiac Output Measurements During Cesarean Delivery Under Spinal Anesthesia. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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