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epinephrine perfusion
Epinephrine (adrenaline) acts as a sympathomimetic agent that binds to alpha and beta adrenergic receptors to increase heart rate, blood pressure, and cardiac output.
Epinephrine (adrenaline) acts as a sympathomimetic agent that binds to alpha and beta adrenergic receptors to increase heart rate, blood pressure, and cardiac output. Used for Cardiogenic shock, Septic shock, Cardiac arrest (advanced life support).
At a glance
| Generic name | epinephrine perfusion |
|---|---|
| Also known as | vasopressor, catecholamine |
| Sponsor | Central Hospital, Nancy, France |
| Drug class | Sympathomimetic amine / Catecholamine |
| Target | Alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular / Critical Care |
| Phase | FDA-approved |
Mechanism of action
Epinephrine is an endogenous catecholamine that stimulates alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors. When administered as a perfusion, it increases myocardial contractility and heart rate (beta-1 effects), causes vasoconstriction (alpha-1 effects), and promotes bronchodilation (beta-2 effects). This results in improved perfusion pressure and oxygen delivery to vital organs.
Approved indications
- Cardiogenic shock
- Septic shock
- Cardiac arrest (advanced life support)
- Severe hypotension
- Anaphylaxis
Common side effects
- Tachycardia
- Hypertension
- Arrhythmias
- Anxiety / Tremor
- Headache
- Tissue necrosis (extravasation)
Key clinical trials
- Treatment of Hypotension of Prematurity (TOHOP) (NA)
- Activation of Brown Adipose Tissue Thermogenesis in Humans Using Formoterol Fumarate (GB10) (NA)
- Metabolic Adaptation to High-frequent Hypoglycaemia in Type 1 Diabetes (NA)
- Sufentanil on Anesthesia Introduction and Recovery Quality in Pediatric Adenotonsillectomy (NA)
- The Effect of Epinephrine, Norepinephrine and Phenylephrine on Intraoperative Hemodynamic Performance (PHASE4)
- Application of Iced Normal Saline Combined With Cocktail Perfusion in Total Knee Arthroplasty (NA)
- VAsopressin and STeroids in Addition to Adrenaline in Cardiac Arrest - a Randomized Clinical Trial (PHASE3)
- Study of Multistep Pharmacological and Invasive Management for Cardiogenic Shock (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- epinephrine perfusion CI brief — competitive landscape report
- epinephrine perfusion updates RSS · CI watch RSS
- Central Hospital, Nancy, France portfolio CI