Epidural analgesia:Levobupivacaine0,125% — Competitive Intelligence Brief

Epidural analgesia:Levobupivacaine0,125% (Epidural analgesia:Levobupivacaine0,125%) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic (amide class). Area: Anesthesia/Pain Management.

phase 3 Local anesthetic (amide class) Voltage-gated sodium channels Anesthesia/Pain Management Small molecule

Target snapshot

Epidural analgesia:Levobupivacaine0,125% (Epidural analgesia:Levobupivacaine0,125%) — Hospital General Universitario Elche. Levobupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce regional anesthesia.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Epidural analgesia:Levobupivacaine0,125% TARGET	Epidural analgesia:Levobupivacaine0,125%	Hospital General Universitario Elche	phase 3	Local anesthetic (amide class)	Voltage-gated sodium channels
Buffered Articaine Hydrochloride + Epinephrine	Buffered Articaine Hydrochloride + Epinephrine	Ohio State University	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component)
Paroxetine+Lamotrigine	Paroxetine+Lamotrigine	Ministry of Health & Welfare, Korea	marketed	SSRI + anticonvulsant mood stabilizer combination	Serotonin transporter (SERT); voltage-gated sodium channels; glutamate release modulation
Dose of prilocaine	Dose of prilocaine	Hospital General Universitario Gregorio Marañon	marketed	Local anesthetic (amide class)	Voltage-gated sodium channels
Levobupivacaine wound infusion	Levobupivacaine wound infusion	University of Genova	marketed	Local anesthetic	Voltage-gated sodium channels
lamotrigine (brand Lamictal)	lamotrigine (brand Lamictal)	University of Maryland, Baltimore	marketed	Anticonvulsant / Mood stabilizer	Voltage-gated sodium channels; glutamate release inhibition
Lidocaine / propofol admixture	Lidocaine / propofol admixture	Benaroya Research Institute	marketed	Local anesthetic / sedative combination	Voltage-gated sodium channels (lidocaine); GABA-A receptor (propofol)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic (amide class) class)

1. Ain Shams University · 2 drugs in this class
2. Başakşehir Çam & Sakura City Hospital · 2 drugs in this class
3. TriHealth Inc. · 2 drugs in this class
4. Centre of Postgraduate Medical Education · 2 drugs in this class
5. Bozyaka Training and Research Hospital · 2 drugs in this class
6. Complejo Hospitalario Universitario de Granada · 1 drug in this class
7. Clinique Saint-Jean, Bruxelles · 1 drug in this class
8. Hospital Clínico Universitario de Valencia · 1 drug in this class
9. Fundacion Clinica Valle del Lili · 1 drug in this class
10. Federal University of Minas Gerais · 1 drug in this class