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Dose of prilocaine
Prilocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Prilocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local and regional anesthesia for infiltration, nerve blocks, and topical use, Dental anesthesia, Minor surgical procedures.
At a glance
| Generic name | Dose of prilocaine |
|---|---|
| Also known as | ED50 of intrathecal hyperbaric prilocaine in ultrasound fusion guided prostate biopsy |
| Sponsor | Hospital General Universitario Gregorio Marañon |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Prilocaine works by reversibly inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, which stabilizes the neuronal membrane and prevents depolarization. This action blocks the conduction of nerve impulses in sensory, motor, and autonomic nerves, resulting in local anesthesia. The drug is metabolized hepatically and has a relatively rapid onset and intermediate duration of action.
Approved indications
- Local and regional anesthesia for infiltration, nerve blocks, and topical use
- Dental anesthesia
- Minor surgical procedures
Common side effects
- Methemoglobinemia
- Allergic reactions
- Systemic toxicity (CNS and cardiac effects at high doses)
- Local tissue irritation
Key clinical trials
- The Additive Effect of Exercise in Addition to Corticosteroid Injection in Plantar Fasciitis (NA)
- Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face (PHASE2, PHASE3)
- Using Three Different Doses of Hyperbaric Prilocaine 2% Local Anaesthetic ( 40,50 and 60mg ),Through Spinal Anaesthesia in Knee Arthroscopy Patients to Compare Time to Void (PHASE3)
- Oral Hyoscine vs. Topical EMLA vs. Placebo for Pain Reduction During Hysterosalpingography (NA)
- Comparison of Dural Puncture Epidural and Standard Epidural Anesthesia Techniques in Elective Cesarean Deliveries (NA)
- Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized Study (NA)
- Comparing the Effect of Spinal Bupivacaine Versus Spinal Prilocaine on Maternal Blood Pressure in Cesarean Section (NA)
- Comparison Between Lidocaine Prilocaine Cream and Lidocaine Injection on Pain Control During Episiotomy. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |