Last reviewed · How we verify
Lidocaine / propofol admixture
A combination of lidocaine (local anesthetic) and propofol (sedative-hypnotic) that provides both local anesthesia and sedation through complementary mechanisms.
A combination of lidocaine (local anesthetic) and propofol (sedative-hypnotic) that provides both local anesthesia and sedation through complementary mechanisms. Used for Procedural sedation and analgesia, Local anesthesia with sedation for medical procedures.
At a glance
| Generic name | Lidocaine / propofol admixture |
|---|---|
| Sponsor | Benaroya Research Institute |
| Drug class | Local anesthetic / sedative combination |
| Target | Voltage-gated sodium channels (lidocaine); GABA-A receptor (propofol) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine blocks sodium channels in nerve fibers to provide local anesthetic effects, while propofol acts as a positive allosteric modulator of GABA-A receptors to produce sedation and hypnosis. This admixture is used to reduce pain and anxiety during procedures while potentially reducing the required dose of propofol alone.
Approved indications
- Procedural sedation and analgesia
- Intravenous anesthesia adjunct
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Apnea
Key clinical trials
- The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability During Anesthesia Induction in Adults. (PHASE4)
- Preventing Propofol-associated Injection Pain (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine / propofol admixture CI brief — competitive landscape report
- Lidocaine / propofol admixture updates RSS · CI watch RSS
- Benaroya Research Institute portfolio CI