{"id":"lidocaine-propofol-admixture","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Injection site pain"},{"rate":null,"effect":"Apnea"}]},"_chembl":{"chemblId":"CHEMBL526","moleculeType":"Small molecule","molecularWeight":"178.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine blocks sodium channels in nerve fibers to provide local anesthetic effects, while propofol acts as a positive allosteric modulator of GABA-A receptors to produce sedation and hypnosis. This admixture is used to reduce pain and anxiety during procedures while potentially reducing the required dose of propofol alone.","oneSentence":"A combination of lidocaine (local anesthetic) and propofol (sedative-hypnotic) that provides both local anesthesia and sedation through complementary mechanisms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:41:07.384Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Procedural sedation and analgesia"},{"name":"Intravenous anesthesia adjunct"}]},"trialDetails":[{"nctId":"NCT05948267","phase":"PHASE4","title":"The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability During Anesthesia Induction in Adults.","status":"COMPLETED","sponsor":"Kasr El Aini Hospital","startDate":"2023-05-25","conditions":"The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability","enrollment":120},{"nctId":"NCT00864682","phase":"PHASE4","title":"Preventing Propofol-associated Injection Pain","status":"COMPLETED","sponsor":"Benaroya Research Institute","startDate":"2008-01","conditions":"Pain","enrollment":156}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Lidocaine / propofol admixture","genericName":"Lidocaine / propofol admixture","companyName":"Benaroya Research Institute","companyId":"benaroya-research-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A combination of lidocaine (local anesthetic) and propofol (sedative-hypnotic) that provides both local anesthesia and sedation through complementary mechanisms. Used for Procedural sedation and analgesia, Local anesthesia with sedation for medical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}