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NCT07276490: PACE-CCQ
Central Haemodynamics and Pacing for AV Block
NA trial testing Right ventricular pacing in Atrioventricular Block in 124 participants. Currently enrolling.
1 June 2027
Quick facts
| Lead sponsor | University of Tartu |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 124 |
| Start date | 28 November 2025 |
| Primary completion | 1 June 2027 |
| Estimated completion | 31 December 2027 |
| Sites | 2 locations across Estonia |
Drugs / interventions tested
- Right ventricular pacing
- Conduction system pacing
Conditions studied
- Atrioventricular Block — all drugs for Atrioventricular Block →
- Pacing Therapy — all drugs for Pacing Therapy →
- Right Ventricular Pacing — all drugs for Right Ventricular Pacing →
- Conduction System Pacing — all drugs for Conduction System Pacing →
Sponsor
University of Tartu
Who can join
Adults 18 to 80, any sex, with Atrioventricular Block or Pacing Therapy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07276490
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Right ventricular pacing
Trials testing the same drug.
- NCT06197503 — Randomized Study of Physiological vs Right Ventricular Pacing in Patients With Normal Ventricular Function Post TAVI · NA · recruiting
- NCT05585411 — PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Pr · NA · recruiting
- NCT04672408 — His Bundle Pacing Versus Right Ventricular Pacing · NA · terminated
- NCT04595487 — LVSP vs RVP in Patients With AV Conduction Disorders · NA · recruiting
- NCT04730921 — Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block) · NA · completed
Other recruiting trials for Atrioventricular Block
Currently open trials in the same condition.
- NCT07250529 — Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF · NA · recruiting
- NCT07209852 — Safety, Performance, and Clinical Benefit of Pacing the Left Bundle Branch Area - Post-Market Clinical Follow-up · recruiting
- NCT07464041 — Left Bundle Branch Area Pacing Versus Right Ventricular Pacing in Atrioventricular Block With Preserved Ejection Fractio · NA · recruiting
- NCT07521800 — Remote ECG Monitoring Post TAVI · NA · recruiting
- NCT05774262 — Pacemaker Implantation Versus Cardioneuroablation for Functional Atrioventricular Block · NA · recruiting
Other University of Tartu trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07276490 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Tartu
- Last refreshed: 9 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07276490.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing