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NCT07250529: LBBP-AHRE
Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF
NA trial testing Right Ventricular Pacing in Atrial Fibrillation (AF) in 244 participants. Currently enrolling.
20 April 2029
Quick facts
| Lead sponsor | University Hospital of Patras |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 244 |
| Start date | 5 February 2026 |
| Primary completion | 20 April 2029 |
| Estimated completion | 20 June 2029 |
| Sites | 1 location across Greece |
Drugs / interventions tested
- Right Ventricular Pacing
- Left Bundle Branch Pacing
Conditions studied
- Atrial Fibrillation (AF) — all drugs for Atrial Fibrillation (AF) →
- Pacemaker Therapy — all drugs for Pacemaker Therapy →
- Atrioventricular Block — all drugs for Atrioventricular Block →
- Preserved Ejection Fraction — all drugs for Preserved Ejection Fraction →
Sponsor
University Hospital of Patras
Who can join
18 and older, any sex, with Atrial Fibrillation (AF) or Pacemaker Therapy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This prospective, randomized controlled trial aims to evaluate the effect of left bundle branch pacing (LBBP) compared with conventional right ventricular (RV) pacing on the cumulative duration (total time) of atrial high-rate episodes (AHREs) in patients with preserved left ventricular ejection fraction (LVEF) who are expected to require frequent ventricular pacing. Atrial High-Rate Episodes (AHREs) are defined as episodes of atrial tachyarrhythmia that are automatically recorded by device diagnostics and detected by implanted cardiac devices. These episodes usually have an atrial rate ≥170 beats per minute and a duration ≥6 minutes. AHREs are linked to a higher risk of thromboembolic events and clinical atrial fibrillation (AF), and they may indicate subclinical AF or other atrial tachyarrhythmias. Chronic RV pacing has been linked to mechanical and electrical dyssynchrony, which may encourage atrial remodeling and the development of AF. LBBP provides a more physiological ventricular activation and may reduce atrial tachyarrhythmia time (AHRE time). Patients with LVEF \>50% and atrioventricular (AV) conduction disorders requiring a dual-chamber pacemaker will be randomized to either conventional RV septal pacing or LBBP.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07250529
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Right Ventricular Pacing
Trials testing the same drug.
- NCT06857201 — RAFT-TAVR PACE: LBBAP Vs. RVP Post-TAVR in Patients Requiring PPI · NA · not yet recruiting
- NCT06298669 — Biventricular Versus Right Ventricular Pacing · NA · terminated
Other recruiting trials for Atrial Fibrillation (AF)
Currently open trials in the same condition.
- NCT07298473 — Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sp · NA · recruiting
- NCT07442175 — Blood Pressure Monitor (TH-75) Atrial Fibrillation Detection Function Clinical Trial · recruiting
- NCT07389434 — Feasibility, Safety, Cost-effectiveness, and Environmental Impact of Reprocessed Ablation Catheters in PVI · NA · recruiting
- NCT07358611 — Non-invasive Mapping-Guided Atrial Fibrillation Ablation · NA · recruiting
- NCT07403760 — Wellbeing and Survival Improvement With Event Reduction by Ablation for Atrial Fibrillation in the Very Elderly · NA · recruiting
Other University Hospital of Patras trials
Trials by the same sponsor.
- NCT07305194 — Study of AHRE Burden in Patients Undergoing Bachmann Bundle Area Pacing and Left Bundle Branch Pacing. · not yet recruiting
- NCT06942260 — Vascular Access Registry · recruiting
- NCT06689111 — Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Pa · NA · recruiting
- NCT05605288 — Distal Versus Conventional Transradial Artery Access for Coronary Catheterization in Patients With STEMI · NA · recruiting
- NCT06257030 — The AMARA (As Much As Reasonably Achievable) Study · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07250529 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital of Patras
- Last refreshed: 13 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07250529.
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