Who is sponsoring NCT06689111?

NCT06689111 is sponsored by University Hospital of Patras.

What drugs are being tested in NCT06689111?

Interventions in NCT06689111: Left bundle branch pacing lead, CRT with the standard method through cs.

What condition does NCT06689111 study?

NCT06689111 studies Heart Failure With Reduced Ejection Fraction (HFrEF).

Is NCT06689111 still recruiting?

NCT06689111 is currently recruiting now. Last updated 5 December 2025.

Last reviewed 2025-12-05 · How we verify

NCT06689111: ECHO-LBBp

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp)

Recruiting now NA Last updated 5 December 2025

What this trial tests

NA trial testing Left bundle branch pacing lead in Heart Failure With Reduced Ejection Fraction (HFrEF) in 100 participants. Currently enrolling.

Timeline

23 May 2024

Primary endpoint
30 September 2026

30 November 2026

Quick facts

Lead sponsor	University Hospital of Patras
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	100
Start date	23 May 2024
Primary completion	30 September 2026
Estimated completion	30 November 2026
Sites	1 location across Greece

Drugs / interventions tested

Left bundle branch pacing lead
CRT with the standard method through cs

Conditions studied

Heart Failure With Reduced Ejection Fraction (HFrEF) — all drugs for Heart Failure With Reduced Ejection Fraction (HFrEF) →

Sponsor

University Hospital of Patras

Who can join

Adults 18 to 90, any sex, with Heart Failure With Reduced Ejection Fraction (HFrEF). Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy. Its primary objective is to investigate whether the presence of a specific echocardiographic contraction pattern before implantation is associated with increased rates of acute improvement in myocardial function (as measured by an ultrasound) and to compare the improvement in two groups of patients based on the type of pacing (biventricular or left-sided pacing)

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Understanding LOT-CRT: Current Insights, Limitations, and Our Center's Experience.
Leventopoulos G, Nastouli KM, Bozika M, Papastavrou E, et al · · 2025 · cited 4× · PMID 40364057 · DOI 10.3390/jcm14093025
Abstracts: 50th International Congress on Electrocardiology.
· 2025 · PMID 40623860 · DOI 10.1111/anec.70099

Verify or expand the search:

Other trials of Left bundle branch pacing lead

Trials testing the same drug.

NCT05015660 — Conduction System Pacing With Left Bundle Branch Pacing as Compared to Standard Right Ventricular Pacing · NA · recruiting

Other recruiting trials for Heart Failure With Reduced Ejection Fraction (HFrEF)

Currently open trials in the same condition.

NCT07518030 — Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure · NA · recruiting
NCT07405944 — Vericiguat and Reverse Remodeling Indices in Heart Failure · Phase 4 · recruiting
NCT06964464 — Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardio · Phase 4 · recruiting
NCT06909682 — AI-Based Monitoring System for Chronic Heart Failure With Advanced Wearable and Mini-Invasive Devices · recruiting
NCT07259512 — Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fra · Phase 4 · recruiting

Other University Hospital of Patras trials

Trials by the same sponsor.

NCT07250529 — Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF · NA · recruiting
NCT07305194 — Study of AHRE Burden in Patients Undergoing Bachmann Bundle Area Pacing and Left Bundle Branch Pacing. · not yet recruiting
NCT06942260 — Vascular Access Registry · recruiting
NCT05605288 — Distal Versus Conventional Transradial Artery Access for Coronary Catheterization in Patients With STEMI · NA · recruiting
NCT06257030 — The AMARA (As Much As Reasonably Achievable) Study · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06689111 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital of Patras
Last refreshed: 5 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06689111.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing