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NCT04730921: LEAP-Block
Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block)
NA trial testing Left bundle branch area pacing in Atrioventricular Block in 486 participants. Completed in 1 December 2025.
30 June 2025
Quick facts
| Lead sponsor | Fu Wai Hospital, Beijing, China |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 486 |
| Start date | 13 November 2020 |
| Primary completion | 30 June 2025 |
| Estimated completion | 1 December 2025 |
| Sites | 8 locations across China |
Drugs / interventions tested
- Left bundle branch area pacing
- Right ventricular pacing
Conditions studied
- Atrioventricular Block — all drugs for Atrioventricular Block →
- Left Bundle Branch Area Pacing — all drugs for Left Bundle Branch Area Pacing →
- Right Ventricular Pacing — all drugs for Right Ventricular Pacing →
- Heart Failure — all drugs for Heart Failure →
Sponsor
Fu Wai Hospital, Beijing, China
Who can join
Adults 18 to 90, any sex, with Atrioventricular Block or Left Bundle Branch Area Pacing. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a multicenter, randomized controlled study. The aim of this study is to compare the impact of LBBAP on left ventricular function as compared with traditional right ventricular pacing in patients with atrioventricular block.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
New Insights into Pacing Induced Cardiomyopathy.
Kim SS, Park HW. · · 2024 · cited 6× · PMID 39076559 · DOI 10.31083/j.rcm2504118 -
Left Bundle Branch Area Pacing over His Bundle Pacing: How Far Have We Come?
Baroni M, Preda A, Varrenti M, Vargiu S, et al · · 2023 · cited 6× · PMID 37176691 · DOI 10.3390/jcm12093251 -
Current Role of Conduction System Pacing in Patients Requiring Permanent Pacing.
Beer D, Vijayaraman P. · · 2024 · cited 4× · PMID 38859643 · DOI 10.4070/kcj.2024.0113 -
Conduction system pacing on track to replace CRT? Review of current evidence and prospects of conduction system pacing.
Moustafa AT, Tang AS, Khan HR. · · 2023 · cited 4× · PMID 37649666 · DOI 10.3389/fcvm.2023.1220709 -
Cardiac Resynchronization Therapy and Conduction System Pacing.
O'Neill TG, Tsushima T, Tayal B. · · 2025 · cited 1× · PMID 40364243 · DOI 10.3390/jcm14093212 -
Safety and efficacy of left bundle branch area pacing compared with right ventricular pacing in patients with bradyarrhythmia and conduction system disorders: a systematic review and meta-analysis
Leventopoulos G, Travlos CK, Aronis KN, Anagnostopoulou V, et al · · 2023 · DOI 10.1101/2023.02.09.23285675
Verify or expand the search:
- PubMed search for NCT04730921
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Left bundle branch area pacing
Trials testing the same drug.
- NCT05884411 — Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-Response · NA · withdrawn
- NCT05585411 — PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Pr · NA · recruiting
- NCT05102227 — Cardiac ResynchronizatiOn and arrhythmiaS Sensing Via the LEFT Bundle. · unknown
Other recruiting trials for Atrioventricular Block
Currently open trials in the same condition.
- NCT07250529 — Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF · NA · recruiting
- NCT07209852 — Safety, Performance, and Clinical Benefit of Pacing the Left Bundle Branch Area - Post-Market Clinical Follow-up · recruiting
- NCT07276490 — Central Haemodynamics and Pacing for AV Block · NA · recruiting
- NCT07464041 — Left Bundle Branch Area Pacing Versus Right Ventricular Pacing in Atrioventricular Block With Preserved Ejection Fractio · NA · recruiting
- NCT07521800 — Remote ECG Monitoring Post TAVI · NA · recruiting
Other Fu Wai Hospital, Beijing, China trials
Trials by the same sponsor.
- NCT07316452 — Risk Prediction of Disease Progression in Early-Onset Coronary Atherosclerosis · recruiting
- NCT06088433 — Ticagrelor Single Antiplatelet Therapy in Patients With High Risk of Bleeding After DCB for Coronary Small Vessel Diseas · Phase 4 · unknown
- NCT06090890 — Anti-inflammatory Therapy for Recurrent In-stent Restenosis · Phase 4 · recruiting
- NCT05985408 — LVSP Based CRT vs. RVAP Based CRT · NA · unknown
- NCT03851315 — Left Bundle Branch Area Pacing in AVB Patients · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04730921 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fu Wai Hospital, Beijing, China
- Last refreshed: 30 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04730921.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing