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NCT03851315
Left Bundle Branch Area Pacing in AVB Patients
trial testing permanent left bundle branch area pacing in Atrioventricular Block in 45 participants. Status unknown.
31 December 2020
Quick facts
| Lead sponsor | Fu Wai Hospital, Beijing, China |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 45 |
| Start date | 1 May 2018 |
| Primary completion | 31 December 2020 |
| Estimated completion | 30 June 2021 |
| Sites | 1 location across China |
Drugs / interventions tested
- permanent left bundle branch area pacing
Conditions studied
- Atrioventricular Block — all drugs for Atrioventricular Block →
- Left Bundle Branch Area Pacing — all drugs for Left Bundle Branch Area Pacing →
Sponsor
Fu Wai Hospital, Beijing, China
Who can join
Adults 18 to 90, any sex, with Atrioventricular Block or Left Bundle Branch Area Pacing. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Right ventricular pacing (RVP) causes left ventricular mechanical dyssynchrony by inducing electrical interventricular and intraventricular dyssynchrony. His bundle pacing may restore the the atrioventricular, interventricular and intraventricular electrical synchronization, however, Increased pacing threshold might result in the early depletion of the pacemaker, and finally brought on pacemaker replacement, which was one of the major causes of device infection. Pacing the left bundle branch beyond the conduction block site might achieve a low and stable output and narrow QRSd. The investigators were prepared to consecutively include patients with atrioventricular block, divided into the left bundle branch area pacing(LBBAP) group and the conventional right ventricular pacing group. The electrophysiological characteristics of LBBAP and right ventricular pacing were compared with ECG characteristics. The left and right ventricular synchrony and left and right cardiac function were evaluated by 3D ultrasound, and the short-term and long-term safety and efficacy of LBBAP were evaluated.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Clinical Outcomes in Patients With Left Bundle Branch Area Pacing vs. Right Ventricular Pacing for Atrioventricular Block.
Li X, Zhang J, Qiu C, Wang Z, et al · · 2021 · cited 40× · PMID 34307499 · DOI 10.3389/fcvm.2021.685253
Verify or expand the search:
- PubMed search for NCT03851315
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Atrioventricular Block
Currently open trials in the same condition.
- NCT07250529 — Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF · NA · recruiting
- NCT07209852 — Safety, Performance, and Clinical Benefit of Pacing the Left Bundle Branch Area - Post-Market Clinical Follow-up · recruiting
- NCT07276490 — Central Haemodynamics and Pacing for AV Block · NA · recruiting
- NCT07464041 — Left Bundle Branch Area Pacing Versus Right Ventricular Pacing in Atrioventricular Block With Preserved Ejection Fractio · NA · recruiting
- NCT07521800 — Remote ECG Monitoring Post TAVI · NA · recruiting
Other Fu Wai Hospital, Beijing, China trials
Trials by the same sponsor.
- NCT07316452 — Risk Prediction of Disease Progression in Early-Onset Coronary Atherosclerosis · recruiting
- NCT06088433 — Ticagrelor Single Antiplatelet Therapy in Patients With High Risk of Bleeding After DCB for Coronary Small Vessel Diseas · Phase 4 · unknown
- NCT06090890 — Anti-inflammatory Therapy for Recurrent In-stent Restenosis · Phase 4 · recruiting
- NCT05985408 — LVSP Based CRT vs. RVAP Based CRT · NA · unknown
- NCT04730921 — Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block) · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03851315 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fu Wai Hospital, Beijing, China
- Last refreshed: 22 February 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03851315.
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