Last reviewed · How we verify
NCT04672408: His-PACE
His Bundle Pacing Versus Right Ventricular Pacing
NA trial testing His bundle pacing in Pacing-Induced Cardiomyopathy in 29 participants. Terminated before completion.
4 April 2025
Quick facts
| Lead sponsor | University Hospital, Geneva |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 29 |
| Start date | 1 August 2021 |
| Primary completion | 4 April 2025 |
| Estimated completion | 4 April 2025 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- His bundle pacing
- Right ventricular pacing
Conditions studied
- Pacing-Induced Cardiomyopathy — all drugs for Pacing-Induced Cardiomyopathy →
Sponsor
University Hospital, Geneva
Who can join
18 and older, any sex, with Pacing-Induced Cardiomyopathy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will randomize cross-over periods of 6 months of right ventricular pacing and His bundle pacing in patients with baseline left ventricular ejection fraction (LVEF)\>40%. The primary outcome measure is LVEF.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Conduction System Pacing for Heart Failure.
Smith NR, Lynch P, Chelu MG. · · 2024 · PMID 39677397 · DOI 10.14503/thij-24-8469
Verify or expand the search:
- PubMed search for NCT04672408
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of His bundle pacing
Trials testing the same drug.
- NCT03294317 — Imaging Study of Lead Implant for His Bundle Pacing · completed
Other recruiting trials for Pacing-Induced Cardiomyopathy
Currently open trials in the same condition.
- NCT06052475 — Physiological Versus Right Ventricular Outcome Trial Evaluated for Bradycardia Treatment Upgrades · NA · recruiting
- NCT05650658 — Left vs Left Randomized Clinical Trial · NA · recruiting
- NCT04595487 — LVSP vs RVP in Patients With AV Conduction Disorders · NA · recruiting
- NCT04416958 — Pacing to Maintain Physiologic Ventricular Activation · recruiting
Other University Hospital, Geneva trials
Trials by the same sponsor.
- NCT07506356 — Investigation of Gastric Emptying by Gastric Ultrasonography in Diabetic Patients Treated With GLP-1 Receptors · recruiting
- NCT07267624 — EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study) · NA · not yet recruiting
- NCT06710210 — Hybrid Percutaneous Coronary Intervention Combining a Bioresorbable Scaffold With Drug-coated Balloons Versus a Conventi · NA · not yet recruiting
- NCT07173348 — Hypnosis on Breathlessness Mastery in Patients With Persistent Dyspnea · NA · not yet recruiting
- NCT07129655 — Cholangitis Definition and Treatment After Kasai Hepatoportoenterostomy for Biliary Atresia: TRACK-BA Study (TRacking Ch · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04672408 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Geneva
- Last refreshed: 9 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04672408.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing