NCT04853797 (ILIM) is a NA clinical trial of Levcromakalim in Headache, sponsored by Danish Headache Center.

Who is sponsoring NCT04853797?

NCT04853797 is sponsored by Danish Headache Center.

What drugs are being tested in NCT04853797?

Interventions in NCT04853797: Levcromakalim, Ivabradine, Placebo.

What condition does NCT04853797 study?

NCT04853797 studies Headache, Migraine Without Aura.

Is NCT04853797 still recruiting?

NCT04853797 is currently completed. Last updated 8 January 2026.

Last reviewed 2026-01-08 · How we verify

NCT04853797: ILIM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Ivabradine on Levcromakalim-Induced Symptoms in Individuals With Migraine Without Aura (ILIM)

Completed NA Last updated 8 January 2026

What this trial tests

NA trial testing Levcromakalim in Headache in 37 participants. Completed in 6 July 2025.

Timeline

11 May 2021

Primary endpoint
6 July 2025

6 July 2025

Quick facts

Lead sponsor	Danish Headache Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	other
Enrollment	37
Start date	11 May 2021
Primary completion	6 July 2025
Estimated completion	6 July 2025
Sites	2 locations across Denmark

Drugs / interventions tested

Levcromakalim — full drug profile →
Ivabradine (IVABRADINE) — full drug profile →
Placebo

Conditions studied

Headache — all drugs for Headache →
Migraine Without Aura — all drugs for Migraine Without Aura →

Sponsor

Danish Headache Center — full company profile →

Who can join

Adults 18 to 60, any sex, with Headache or Migraine Without Aura. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to explore the effect of Ivabradine on Levcromakalim-induced migraine in individuals with migraine without aura.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential.
Clement A, Guo S, Jansen-Olesen I, Christensen SL. · · 2022 · cited 18× · PMID 35954249 · DOI 10.3390/cells11152406
Migraine induced by vascular K<sub>ATP</sub> channel activation is independent of HCN channel activity: A randomised controlled trial with translational validation.
Zhuang ZA, Thuraiaiyah J, Kokoti L, Moreno RD, et al · · 2026 · PMID 41930571 · DOI 10.1177/03331024261431770

Verify or expand the search:

Other trials of Levcromakalim

Trials testing the same drug.

NCT05889442 — Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab · NA · completed
NCT05565001 — The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. · NA · unknown
NCT05243953 — Hypersensitivity to Opening of ATP-Sensitive Potassium Channels in Post-Traumatic Headache · NA · completed
NCT05211050 — Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine · NA · completed
NCT04905654 — Migraine Inducing Effect of Levcromakalim in Patients With Migraine With Aura · NA · completed

Other recruiting trials for Headache

Currently open trials in the same condition.

NCT07487649 — Treatment Response in Patients With Medication-Overuse Headache · recruiting
NCT07097792 — Concussion Recovery and Support Program · NA · recruiting
NCT06225817 — Placebo Impacts Sleep and Pain Modulation in Chronic Pain · NA · recruiting
NCT06310200 — Sphenopalatine Ganglion Block and Cold Induced Headaches · Phase 1 · active not recruiting
NCT07404956 — THE EFFECT OF SURGICAL MASK AND N95 MASK USE ON SURGICAL SMOKE IN OPERATING ROOM NURSES · NA · recruiting

Other Danish Headache Center trials

Trials by the same sponsor.

NCT07451769 — Selective Activation of the Adrenomedullin Receptors in Migraine · NA · not yet recruiting
NCT07342296 — Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38 · NA · not yet recruiting
NCT07059546 — Hypersensitivity to Adrenomedullin in Post-Traumatic Headache · NA · recruiting
NCT07021859 — Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide · NA · recruiting
NCT06959004 — Substance P-Induced Migraine Attacks Without Aura · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04853797 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Danish Headache Center
Last refreshed: 8 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04853797.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing