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NCT04905654
Migraine Inducing Effect of Levcromakalim in Patients With Migraine With Aura
NA trial testing Levcromakalim in Headache, Migraine in 35 participants. Completed in 16 May 2023.
16 May 2023
Quick facts
| Lead sponsor | Danish Headache Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | other |
| Enrollment | 35 |
| Start date | 29 September 2021 |
| Primary completion | 16 May 2023 |
| Estimated completion | 16 May 2023 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Levcromakalim — full drug profile →
- Saline
Conditions studied
- Headache, Migraine — all drugs for Headache, Migraine →
- Aura — all drugs for Aura →
Sponsor
Danish Headache Center — full company profile →
Who can join
Adults 18 to 70, any sex, with Headache, Migraine or Aura. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To investigate the migraine inducing effect of levcromakalim in patients with migraine with aura.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Investigations of the migraine-provoking effect of levcromakalim in patients with migraine with aura.
Thomsen AV, Al-Karagholi MA, Hougaard A, Ostrowski SR, et al · · 2024 · cited 8× · PMID 38501895 · DOI 10.1177/03331024241237247 -
Effects of levcromakalim in patients with migraine aura without headache: An experimental study.
Thomsen AV, Al-Karagholi MA, Hougaard A, Ostrowski SR, et al · · 2024 · cited 1× · PMID 39161224 · DOI 10.1177/03331024241274366
Verify or expand the search:
- PubMed search for NCT04905654
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Levcromakalim
Trials testing the same drug.
- NCT05889442 — Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab · NA · completed
- NCT05565001 — The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. · NA · unknown
- NCT05243953 — Hypersensitivity to Opening of ATP-Sensitive Potassium Channels in Post-Traumatic Headache · NA · completed
- NCT05211050 — Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine · NA · completed
- NCT05093582 — The Effects of Levcromakalim in Patients With Cluster Headache · NA · completed
Other recruiting trials for Headache, Migraine
Currently open trials in the same condition.
- NCT06584409 — Migraines Accepted Laser Acupuncture Compared in Blood Test of MMP2 and CGRP · NA · recruiting
- NCT05889624 — Responding With Evidence and Access for Childhood Headaches · NA · recruiting
- NCT05232942 — Monoclonal Antibody Duration of REsponse in MIgraine After Treatment Interruption · recruiting
- NCT04715685 — Mind Body Balance for Pediatric Migraine · NA · recruiting
Other Danish Headache Center trials
Trials by the same sponsor.
- NCT07451769 — Selective Activation of the Adrenomedullin Receptors in Migraine · NA · not yet recruiting
- NCT07342296 — Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38 · NA · not yet recruiting
- NCT07059546 — Hypersensitivity to Adrenomedullin in Post-Traumatic Headache · NA · recruiting
- NCT07021859 — Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide · NA · recruiting
- NCT06959004 — Substance P-Induced Migraine Attacks Without Aura · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04905654 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Danish Headache Center
- Last refreshed: 17 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04905654.
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