NCT05565001 is a NA clinical trial of Levcromakalim in Headache, sponsored by Danish Headache Center.

Who is sponsoring NCT05565001?

NCT05565001 is sponsored by Danish Headache Center.

What drugs are being tested in NCT05565001?

Interventions in NCT05565001: Levcromakalim.

What condition does NCT05565001 study?

NCT05565001 studies Headache, Migraine With Aura, Migraine Without Aura.

Is NCT05565001 still recruiting?

NCT05565001 is currently status unknown. Last updated 22 March 2023.

Last reviewed 2023-03-22 · How we verify

NCT05565001

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.

Status unknown NA Last updated 22 March 2023

What this trial tests

NA trial testing Levcromakalim in Headache in 20 participants. Status unknown.

Timeline

1 September 2022

Primary endpoint
31 July 2023

31 July 2023

Quick facts

Lead sponsor	Danish Headache Center
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	other
Enrollment	20
Start date	1 September 2022
Primary completion	31 July 2023
Estimated completion	31 July 2023
Sites	1 location across Denmark

Drugs / interventions tested

Levcromakalim — full drug profile →

Conditions studied

Headache — all drugs for Headache →
Migraine With Aura — all drugs for Migraine With Aura →
Migraine Without Aura — all drugs for Migraine Without Aura →

Sponsor

Danish Headache Center — full company profile →

Who can join

Adults 18 to 60, any sex, with Headache or Migraine With Aura. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the present study to investigate whether * Opening of KATP channels causes migraine pain by activation of meningeal nociceptors and ascending trigeminal nociceptive pathways. * Opening of KATP channels causes migraine aura by induction of CSD.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Novel Therapeutic Targets for Migraine.
Nisar A, Ahmed Z, Yuan H. · · 2023 · cited 11× · PMID 36831105 · DOI 10.3390/biomedicines11020569

Verify or expand the search:

Other trials of Levcromakalim

Trials testing the same drug.

NCT05889442 — Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab · NA · completed
NCT05243953 — Hypersensitivity to Opening of ATP-Sensitive Potassium Channels in Post-Traumatic Headache · NA · completed
NCT05211050 — Effect of Sumatriptan on Levcromakalim-Induced Symptoms in Individuals With Migraine · NA · completed
NCT04905654 — Migraine Inducing Effect of Levcromakalim in Patients With Migraine With Aura · NA · completed
NCT05093582 — The Effects of Levcromakalim in Patients With Cluster Headache · NA · completed

Other recruiting trials for Headache

Currently open trials in the same condition.

NCT07487649 — Treatment Response in Patients With Medication-Overuse Headache · recruiting
NCT07097792 — Concussion Recovery and Support Program · NA · recruiting
NCT06225817 — Placebo Impacts Sleep and Pain Modulation in Chronic Pain · NA · recruiting
NCT06310200 — Sphenopalatine Ganglion Block and Cold Induced Headaches · Phase 1 · active not recruiting
NCT07404956 — THE EFFECT OF SURGICAL MASK AND N95 MASK USE ON SURGICAL SMOKE IN OPERATING ROOM NURSES · NA · recruiting

Other Danish Headache Center trials

Trials by the same sponsor.

NCT07451769 — Selective Activation of the Adrenomedullin Receptors in Migraine · NA · not yet recruiting
NCT07342296 — Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38 · NA · not yet recruiting
NCT07059546 — Hypersensitivity to Adrenomedullin in Post-Traumatic Headache · NA · recruiting
NCT07021859 — Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide · NA · recruiting
NCT06959004 — Substance P-Induced Migraine Attacks Without Aura · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05565001 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Danish Headache Center
Last refreshed: 22 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05565001.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing