NCT02707029

Clinical and Scientific Assessment of Pain and Painful Disorders

Recruiting now Last updated 24 February 2026

What this trial tests

trial in Normal Physiology in 10,000 participants. Currently enrolling.

Timeline

22 July 2016

Primary endpoint
9 February 2027

9 February 2027

Quick facts

Lead sponsor	National Center for Complementary and Integrative Health (NCCIH)
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	10,000
Start date	22 July 2016
Primary completion	9 February 2027
Estimated completion	9 February 2027
Sites	1 location across United States

Conditions studied

• Normal Physiology — all drugs for Normal Physiology →
• Pain — all drugs for Pain →

Sponsor

National Center for Complementary and Integrative Health (NCCIH) — full company profile →

Who can join

Adults 12 to 120, any sex, with Normal Physiology or Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

Researchers want to better understand pain by studying people with and without different kinds of pain. To do this, researchers will expose people to pleasant and unpleasant sensations. They will ask them questions about their pain. Researchers also want to see if these people are eligible for other research studies at the National Center for Complementary and Integrative Health.

Objectives:

To study the experience of pain. Also to find people eligible to join other NIH studies.

Eligibility:

People 12 years and older with and without pain disorders.

Design:

Participants will be screened by phone.

Participants will have one required visit lasting about 2 hours. This may include:

* Medical history
* Physical exam
* Questionnaires about themselves and their pain experience
* Blood and urine tests
* MRI: They will lie on a table that slides into a cylinder. They will feel different sensations while completing tasks on a computer. This lasts 15 minutes to 2 hours.
* Quantitative sensory testing: They will be exposed to different pictures, sounds, tastes, and smells. They will also be exposed to pleasant and unpleasant sensations. These could include:

* Burning, itching, or cold sensations
* Pinpricks
* Pressure and pinches
* Electrocardiogram: Stickers on the chest record heart activity.
* Straps placed around the chest to measure breathing.
* Small sensors on the fingers or palms to measure pulse and sweating.

Participants may have up to 12 other outpatient study visits.

Participants may be recorded at the visits.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Test-Retest Reliability of an Adaptive Thermal Pain Calibration Procedure in Healthy Volunteers.
   Amir C, Rose-McCandlish M, Weger R, Dildine TC, et al · · 2022 · cited 19× · PMID 35189353 · DOI 10.1016/j.jpain.2022.01.011