Last reviewed · How we verify
NCT03952624
Patient-Centered Assessment of Symptoms and Outcomes
trial in Fatigue in 692 participants. Currently enrolling.
1 June 2026
Quick facts
| Lead sponsor | National Center for Complementary and Integrative Health (NCCIH) |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 692 |
| Start date | 13 September 2019 |
| Primary completion | 1 June 2026 |
| Estimated completion | 1 July 2026 |
| Sites | 1 location across United States |
Conditions studied
- Fatigue — all drugs for Fatigue →
- Cancer — all drugs for Cancer →
- CFS — all drugs for CFS →
- ME/CFS — all drugs for ME/CFS →
Sponsor
National Center for Complementary and Integrative Health (NCCIH) — full company profile →
Who can join
18 and older, any sex, with Fatigue or Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: The cause of fatigue is not well understood. It can be felt differently by different people. Some people think there are different types of fatigue, with different causes. Researchers think a therapy to treat one type of fatigue in one condition should be able to treat that type of fatigue in other conditions. Objective: To understand the types of fatigue. Eligibility: Adults 18 and older who have felt fatigue for more than a month, and non-fatigued adults Design: Participants will be screened with a physical exam, their medical history, a vision test, and blood and urine tests. Participants will begin to track the foods they eat. This study will involve up to 10 visits. Each visit will last no more than 4 hours. In Stage 1, participants will have an interview, fill out questionnaires, and play computer games. They will take walking and handgrip tests. They will give blood, urine, and saliva samples. They will wear a wrist monitor at home for 7 days and write down their activities. They will be put into a group: fatigue or non-fatigued control. In Stage 2, participants will answer questionnaires and give a blood sample. They will have heart tests. They may take exercise and lung function tests that include wearing a nose clip. They may have an optional brain MRI: They may wear an electrode cap on their head during the scan to measure brain activity. They will lie on table that slides into a cylinder. They may perform tasks in the scanner. After the study, participants might be contacted about other studies.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Defining fatigue from the experiences of patients living with chronic fatigue.
Rio CJ, Gehling GM, Blumhorst C, Ross A, et al · · 2024 · cited 6× · PMID 39224606 · DOI 10.3389/fmed.2024.1429275
Verify or expand the search:
- PubMed search for NCT03952624
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Fatigue
Currently open trials in the same condition.
- NCT07073963 — Virtual Patient Groups for Sarcoidosis Associated Fatigue · NA · recruiting
- NCT07421960 — Investigation of the Relationship Between Periodontitis and Sleep Quality · recruiting
- NCT07071324 — CF Wellness Program · NA · recruiting
- NCT07386691 — Comparing Effect of Intradialytic Aerobic Exercise Versus Incentive Spirometer on Fatigue and Sleep Quality Among Hemodi · NA · active not recruiting
- NCT06819254 — Pilot Study of Fisetin to Improve Fatigue Among Older Adult Cancer Survivors · Phase 4 · recruiting
Other National Center for Complementary and Integrative Health (NCCIH) trials
Trials by the same sponsor.
- NCT07504601 — Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers · Phase 2 · not yet recruiting
- NCT06052631 — Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused · recruiting
- NCT03937778 — Sensory Afferents for Deep Pressure Sensation · NA · completed
- NCT03258580 — Sociocultural & Biobehavioral Influences on Pain Expression and Assessment · NA · recruiting
- NCT03096353 — Sensory and Opioid Mechanisms of Affective Touch · EARLY_PHASE1 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03952624 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Center for Complementary and Integrative Health (NCCIH)
- Last refreshed: 15 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03952624.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing