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NCT06052631
Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 Gene
trial in PIEZO2-Deficiency Syndrome in 16 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | National Center for Complementary and Integrative Health (NCCIH) |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 16 |
| Start date | 22 April 2026 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across United States |
Conditions studied
- PIEZO2-Deficiency Syndrome — all drugs for PIEZO2-Deficiency Syndrome →
Sponsor
National Center for Complementary and Integrative Health (NCCIH) — full company profile →
Who can join
Adults 18 to 100, any sex, with PIEZO2-Deficiency Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: PIEZO2 Deficiency Syndrome (PDS) is a genetic disorder that affects a person s ability to feel touches and pain. Researchers want to know more about how PDS changes nerve function. Objective: To compare nerve function in people with PDS to that in people without PDS. Eligibility: People aged 18 years and older with PDS enrolled in protocol 16-AT-0077. Healthy volunteers are also needed. Design: Participants will have at least 1 clinic visit. They will undergo a test that measures activity in the nerves. For the test: Participants will place their arm or leg in a comfortable position. Ultrasound will be used to locate nerves. A smooth wand will be slid over the skin to capture images of the structures below. Two thin needles will be inserted through the skin. These needles are much smaller than the kind used to draw blood. The needles will record nerve activity as different sensations are applied to the skin. These include mild electrical pulses; heat and cold; bending of the knee or elbow; vibration; air puffs; pulling a hair; and tapping, stroking (brushing), stretching, pinching, and pushing on the skin at different levels of force. Each test takes 5 to 10 minutes. Participants will describe the sensations they feel. Participants may opt for an additional test that measures how nerves respond after heat pulses are used to create mild redness on the skin. Researchers would like at least 2 tests from each person. Participants may return for up to 3 additional visits, if desired, to complete all the testing.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06052631
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Related trials
Other National Center for Complementary and Integrative Health (NCCIH) trials
Trials by the same sponsor.
- NCT07504601 — Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers · Phase 2 · not yet recruiting
- NCT03952624 — Patient-Centered Assessment of Symptoms and Outcomes · recruiting
- NCT03937778 — Sensory Afferents for Deep Pressure Sensation · NA · completed
- NCT03258580 — Sociocultural & Biobehavioral Influences on Pain Expression and Assessment · NA · recruiting
- NCT03096353 — Sensory and Opioid Mechanisms of Affective Touch · EARLY_PHASE1 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06052631 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Center for Complementary and Integrative Health (NCCIH)
- Last refreshed: 17 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06052631.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing