NCT02522806 (BEONE) is a NA clinical trial of endometrial biopsy in Sterility, Female, sponsored by Centre Hospitalier Universitaire de Saint Etienne.

Who is sponsoring NCT02522806?

NCT02522806 is sponsored by Centre Hospitalier Universitaire de Saint Etienne.

What drugs are being tested in NCT02522806?

Interventions in NCT02522806: endometrial biopsy.

What condition does NCT02522806 study?

NCT02522806 studies Sterility, Female.

Is NCT02522806 still recruiting?

NCT02522806 is currently completed. Last updated 18 November 2019.

Last reviewed 2019-11-18 · How we verify

NCT02522806: BEONE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Endometrial Local Injury Before First IVF : Evaluation of Pregnancy Rate

Completed NA Last updated 18 November 2019

What this trial tests

NA trial testing endometrial biopsy in Sterility, Female in 315 participants. Completed in 10 April 2019.

Timeline

23 September 2014

Primary endpoint
10 April 2019

10 April 2019

Quick facts

Lead sponsor	Centre Hospitalier Universitaire de Saint Etienne
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	315
Start date	23 September 2014
Primary completion	10 April 2019
Estimated completion	10 April 2019
Sites	1 location across France

Drugs / interventions tested

endometrial biopsy

Conditions studied

Sterility, Female — all drugs for Sterility, Female →

Sponsor

Centre Hospitalier Universitaire de Saint Etienne

Who can join

18 and older, female only, with Sterility, Female. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In spite of all progress realized in the field of assisted reproduction the pregnancy rate by In vitro fertilization (IVF) in France, across indications, is only 23% after IVF cycle. Different causes may account for these failures and that, during all stages of pregnancy. Recent studies have investigated an essential step in fecundation : uterine receptivity. Some teams have shown that a lot of immunological factors would have very significant in this step, by them possible expression in this process. Other studies looked at genes modulation, essential to implantation, with endometrium manipulation, simple, such as endometrial biopsy (EB). The last findings published on this subject, but after 2 IVF failures, are most encouraging because the pregnancy rate for these teams after just endometrial local injury (EB after 2 IVF failures) is well above their usual pregnancy rate. Some teams have focused on immunoassay of endometrial biopsy, in order to profile uterine receptivity and suggest with results, suitable treatment for each patient (ongoing study). EB is quick, easy, make in a simple consultation and with a low cost, contrary to immunological study, which depend of ultra-specialized laboratories and therefore with an important cost.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Endometrial injury in women undergoing in vitro fertilisation (IVF).
Lensen SF, Armstrong S, Gibreel A, Nastri CO, et al · · 2021 · cited 31× · PMID 34110001 · DOI 10.1002/14651858.cd009517.pub4
Endometrial biopsy performed before the first in vitro fertilization does not impact the early pregnancy rate.
Cellier M, Werlen S, Mery L, Genod A, et al · · 2024 · cited 1× · PMID 38212636 · DOI 10.1038/s41598-023-50715-y

Verify or expand the search:

Other trials of endometrial biopsy

Trials testing the same drug.

NCT07496905 — The Effect of the Valsalva Maneuver in Endometrial Biopsy: A Randomized Controlled Trial · NA · recruiting
NCT04079959 — Endometrial Leucocytes Around the Time of Embryo Implantation in Women Undergoing in IVF-ET · unknown
NCT02713854 — BAP-EB as a Predictive Tool for Endometrial Receptivity and Pregnancy Outcome of IVF Treatment · NA · completed
NCT02197923 — Norwegian Adenomyosis Study II: Gene Expression Profiling of Adenomyosis · unknown

Other recruiting trials for Sterility, Female

Currently open trials in the same condition.

NCT05279560 — Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation · NA · active not recruiting

Other Centre Hospitalier Universitaire de Saint Etienne trials

Trials by the same sponsor.

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NCT07483710 — Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission an · NA · not yet recruiting
NCT06845176 — Combining Motor Imagery and Tendon Vibration on the Effectiveness of Motor Imagery · NA · recruiting
NCT07344298 — Less is Better? Effectiveness of a Short Local Vibration Protocol on Neuromuscular Function · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02522806 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier Universitaire de Saint Etienne
Last refreshed: 18 November 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02522806.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing