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NCT02713854
BAP-EB as a Predictive Tool for Endometrial Receptivity and Pregnancy Outcome of IVF Treatment
NA trial testing endometrial biopsy in Subfertility in 240 participants. Completed in 13 September 2021.
4 July 2020
Quick facts
| Lead sponsor | The University of Hong Kong |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 240 |
| Start date | 1 February 2017 |
| Primary completion | 4 July 2020 |
| Estimated completion | 13 September 2021 |
| Sites | 1 location across China |
Drugs / interventions tested
- endometrial biopsy
Conditions studied
- Subfertility — all drugs for Subfertility →
Sponsor
The University of Hong Kong
Who can join
Adults 18 to 42, female only, with Subfertility. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To determine the predictive value of attachment rate of human embryonic stem cells (hESC)-derived trophoblast spheroids (BAP-EB, embryo surrogate) onto endometrial epithelial cells (EEC) on success of IVF treatment and to use the model to identify EEC surface biomarkers for endometrial receptivity.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Application of Stem Cell Therapy for Infertility.
Saha S, Roy P, Corbitt C, Kakar SS. · · 2021 · cited 54× · PMID 34203240 · DOI 10.3390/cells10071613 -
Advancements in Human Embryonic Stem Cell Research: Clinical Applications and Ethical Issues.
Park SJ, Kim YY, Han JY, Kim SW, et al · · 2024 · cited 29× · PMID 38502279 · DOI 10.1007/s13770-024-00627-3 -
Attachment of a trophoblastic spheroid onto endometrial epithelial cells predicts cumulative live birth in women aged 35 and older.
Lee YL, Ruan H, Lee KC, Fong SW, et al · · 2023 · cited 6× · PMID 36940739 · DOI 10.1016/j.fertnstert.2023.03.013 -
Addressing the challenges of immunogenicity, heterogeneity and tumorigenicity in the clinical translation of human embryonic stem cells.
Xia L, Qin J, Ye S. · · 2025 · PMID 41291912 · DOI 10.1186/s13287-025-04826-0
Verify or expand the search:
- PubMed search for NCT02713854
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02713854 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The University of Hong Kong
- Last refreshed: 4 March 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02713854.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing