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NCT02713854

BAP-EB as a Predictive Tool for Endometrial Receptivity and Pregnancy Outcome of IVF Treatment

Completed NA Last updated 4 March 2022
What this trial tests

NA trial testing endometrial biopsy in Subfertility in 240 participants. Completed in 13 September 2021.

Timeline
1 February 2017
Primary endpoint
4 July 2020
13 September 2021

Quick facts

Lead sponsorThe University of Hong Kong
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposediagnostic
Enrollment240
Start date1 February 2017
Primary completion4 July 2020
Estimated completion13 September 2021
Sites1 location across China

Drugs / interventions tested

Conditions studied

Sponsor

The University of Hong Kong

Who can join

Adults 18 to 42, female only, with Subfertility. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To determine the predictive value of attachment rate of human embryonic stem cells (hESC)-derived trophoblast spheroids (BAP-EB, embryo surrogate) onto endometrial epithelial cells (EEC) on success of IVF treatment and to use the model to identify EEC surface biomarkers for endometrial receptivity.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Application of Stem Cell Therapy for Infertility.
    Saha S, Roy P, Corbitt C, Kakar SS. · · 2021 · cited 54× · PMID 34203240 · DOI 10.3390/cells10071613
  2. Advancements in Human Embryonic Stem Cell Research: Clinical Applications and Ethical Issues.
    Park SJ, Kim YY, Han JY, Kim SW, et al · · 2024 · cited 29× · PMID 38502279 · DOI 10.1007/s13770-024-00627-3
  3. Attachment of a trophoblastic spheroid onto endometrial epithelial cells predicts cumulative live birth in women aged 35 and older.
    Lee YL, Ruan H, Lee KC, Fong SW, et al · · 2023 · cited 6× · PMID 36940739 · DOI 10.1016/j.fertnstert.2023.03.013
  4. Addressing the challenges of immunogenicity, heterogeneity and tumorigenicity in the clinical translation of human embryonic stem cells.
    Xia L, Qin J, Ye S. · · 2025 · PMID 41291912 · DOI 10.1186/s13287-025-04826-0

Verify or expand the search:

Other trials of endometrial biopsy

Trials testing the same drug.

Other recruiting trials for Subfertility

Currently open trials in the same condition.

Other The University of Hong Kong trials

Trials by the same sponsor.

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02713854.

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