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NCT07496905
The Effect of the Valsalva Maneuver in Endometrial Biopsy: A Randomized Controlled Trial
NA trial testing endometrial biopsy in Pain in Endometrial Biopsy in 120 participants. Currently enrolling.
1 December 2026
Quick facts
| Lead sponsor | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | other |
| Enrollment | 120 |
| Start date | 1 January 2025 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 December 2026 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- endometrial biopsy
- Tenaculum Application
- Valsalva Maneuver
Conditions studied
- Pain in Endometrial Biopsy — all drugs for Pain in Endometrial Biopsy →
- Abnormal Uterine Bleeding — all drugs for Abnormal Uterine Bleeding →
Sponsor
Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Who can join
Adults 18 to 55, female only, with Pain in Endometrial Biopsy or Abnormal Uterine Bleeding. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Endometrial sampling with a pipelle is a common procedure used to collect a small sample from the lining of the uterus. During the procedure, the cervix is sometimes held with a surgical instrument called a tenaculum, which may cause pain and anxiety for some women. The Valsalva maneuver is a simple technique in which a person takes a deep breath and pushes as if trying to exhale forcefully. This increases pressure inside the abdomen and may help keep the uterus and cervix more stable during the procedure. This study aims to compare pipelle sampling performed with the Valsalva maneuver to the standard method using a tenaculum. The study will evaluate whether the Valsalva maneuver can reduce pain and anxiety while maintaining procedure success and improving patient satisfaction.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07496905
- Europe PMC full search
- ASCO Meeting Library
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07496905 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
- Last refreshed: 27 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07496905.
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