Who is sponsoring NCT05279560?

NCT05279560 is sponsored by University of Luebeck.

What drugs are being tested in NCT05279560?

Interventions in NCT05279560: autologous PRP (platelet rich plasma), Saline solution (NaCL) Injection.

What condition does NCT05279560 study?

NCT05279560 studies Premature Ovarian Insufficiency, Infertility, Female, Sterility, Female, PRP.

Is NCT05279560 still recruiting?

NCT05279560 is currently active, enrolled. Last updated 4 June 2025.

Last reviewed 2025-06-04 · How we verify

NCT05279560: OPIF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation

Active, enrolled NA Last updated 4 June 2025

What this trial tests

NA trial testing autologous PRP (platelet rich plasma) in Premature Ovarian Insufficiency in 114 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

17 March 2022

Primary endpoint
30 April 2025

30 June 2030

Quick facts

Lead sponsor	University of Luebeck
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	114
Start date	17 March 2022
Primary completion	30 April 2025
Estimated completion	30 June 2030
Sites	1 location across Germany

Drugs / interventions tested

autologous PRP (platelet rich plasma) — full drug profile →
Saline solution (NaCL) Injection

Conditions studied

Premature Ovarian Insufficiency — all drugs for Premature Ovarian Insufficiency →
Infertility, Female — all drugs for Infertility, Female →
Sterility, Female — all drugs for Sterility, Female →
PRP — all drugs for PRP →

Sponsor

University of Luebeck

Who can join

Adults 18 to 42, female only, with Premature Ovarian Insufficiency or Infertility, Female. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary objective is to investigate the efficacy, defined as an increase in oocyte numbers upon ovarian stimulation, and safety of a single intra-ovarian PRP injection vs. saline solution (NaCl) injection (Placebo) transvaginally or laparoscopically for follicular activation in patients with child wish and with low ovarian reserve/expected poor ovarian response planning to undergo IVF or ICSI using own eggs. Pain score as numerical rating score and validated quality of life questionnaire will be requested after the procedure. Longterm follow-up of all participants will be performed 1, 2 and 5 years after end of study.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Autologous platelet-rich plasma for assisted reproduction.
Vaidakis D, Papapanou M, Siristatidis CS. · · 2024 · cited 20× · PMID 38682756 · DOI 10.1002/14651858.cd013875.pub2
Therapeutic roles of platelet-rich plasma to restore female reproductive and endocrine dysfunction.
Wang X, Li J, Lu W, Gao F, et al · · 2024 · cited 8× · PMID 38654928 · DOI 10.3389/fendo.2024.1374382
Platelet-Rich Plasma (PRP) in Reproductive Medicine: A Critical Review of PRP Therapy in Low-Reserve and Premature Ovarian Insufficiency.
Moustakli E, Potiris A, Zikopoulos A, Zachariou A, et al · · 2025 · cited 2× · PMID 40427083 · DOI 10.3390/biomedicines13051257
Research trends on platelet-rich plasma in improving ovarian dysfunction: A bibliometric and visualization analysis.
Liu F, Li J, Li J, Lan M, et al · · 2025 · PMID 41079455 · DOI 10.1016/j.reth.2025.09.010

Verify or expand the search:

Other recruiting trials for Premature Ovarian Insufficiency

Currently open trials in the same condition.

NCT07510139 — A Clinical Study of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Premature Ovarian Insuffi · Phase 1, PHASE2 · active not recruiting
NCT06851754 — Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency · Phase 3 · recruiting
NCT07275671 — Microbiome and Premature Ovarian Insufficiency · recruiting
NCT06645379 — Application of Platelet-rich Plasma (PRP) in Reproductive Medicine · NA · recruiting
NCT06481969 — Application of Autologous Adipose Stromal Vascular Fraction in the Treatment of Premature Ovarian Insufficiency · NA · recruiting

Other University of Luebeck trials

Trials by the same sponsor.

NCT06598280 — Same-Day Discharge Versus Overnight Stay Following Pulmonary Vein Isolation for Atrial Fibrillation · NA · recruiting
NCT06493994 — Myval TransAXillary Transcatheter Aortic Valve Replacement Multicenter Clinical Registry · recruiting
NCT05846412 — Treatment of Functional Mitral Regurgitation in Patients With Atrial Fibrillation · NA · unknown
NCT05710822 — QDOT Based PVI for Atrial Fibrillation Treatment - The peQasus Study · unknown
NCT05563142 — Venous Vascular Closure System Versus Manual Compression Following Single Shot Device AF Ablation · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05279560 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Luebeck
Last refreshed: 4 June 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05279560.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing