What drugs target Bacterial cell membrane?

9+ drugs target Bacterial cell membrane, including daptomycin (up to 14 days), Daptomycin for Injection, CHG antiseptic body cleanser, Cetylpyridinium Chloride Buccal Tablets.

Bacterial cell membrane — Drug Target

9 drugs 4 marketed 4 in Phase 3

All drugs that target Bacterial cell membrane — marketed and clinical-stage. Includes 7 drug classes acting on this target.

Drug classes

Cyclic lipopeptide antibiotic · Antimicrobial antiseptic · Quaternary ammonium antimicrobial agent · Antimicrobial peptide · Antimicrobial agent / Antiseptic · Antimicrobial oral rinse / Antiseptic · Antibiotic

Marketed (4)

daptomycin (up to 14 days) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) · Cyclic lipopeptide antibiotic · Infectious Disease
Daptomycin binds to bacterial cell membranes and causes rapid depolarization, leading to loss of essential ions and bacterial cell death.
Daptomycin for Injection · Todd C. Lee MD MPH FIDSA · Cyclic lipopeptide antibiotic · Infectious Disease
Daptomycin disrupts bacterial cell membrane integrity by inserting into the lipid bilayer and causing depolarization and potassium efflux, leading to bacterial cell death.
CHG antiseptic body cleanser · Baycrest · Antimicrobial antiseptic · Infection Prevention / Dermatology
CHG (chlorhexidine gluconate) is an antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, providing broad-spectrum antiseptic activity.
Cetylpyridinium Chloride Buccal Tablets · Peking University People's Hospital · Quaternary ammonium antimicrobial agent · Oral/Dental
Cetylpyridinium chloride is a cationic antimicrobial agent that disrupts bacterial cell membranes and inhibits microbial growth in the oral cavity.

Phase 3 pipeline (4)

MSI-78 · Abeona Therapeutics, Inc · Antimicrobial peptide · Infectious Disease
MSI-78 is an antimicrobial peptide that disrupts bacterial cell membranes to treat infections caused by multidrug-resistant pathogens.
Chlorhexidine gluconate at 0.12% · Universidad de Guanajuato · Antimicrobial agent / Antiseptic · Infectious Disease / Oral Health
Chlorhexidine gluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects.
Topical pexiganan cream 0.8% · Dipexium Pharmaceuticals, Inc. · Antimicrobial peptide · Infectious Disease / Dermatology
Pexiganan is an antimicrobial peptide that disrupts bacterial cell membranes, killing a broad spectrum of bacteria including antibiotic-resistant strains.
Chlorhexidine mouthwash (0.2%) · Al-Mustansiriyah University · Antimicrobial oral rinse / Antiseptic · Dentistry / Oral Health
Chlorhexidine mouthwash disrupts bacterial cell membranes and precipitates bacterial proteins, providing broad-spectrum antimicrobial activity in the oral cavity.

Phase 2 pipeline (1)

BV100 plus Polymyxin B · BioVersys AG · Antibiotic · Infectious Disease
BV100 targets the bacterial cell membrane, disrupting its integrity and leading to cell death, in combination with Polymyxin B, an antibiotic that targets the bacterial cell wall.