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Chlorhexidine gluconate at 0.12%
Chlorhexidine gluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects.
Chlorhexidine gluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects. Used for Oral rinse for reduction of plaque and gingivitis, Antimicrobial oral care in Phase 3 development.
At a glance
| Generic name | Chlorhexidine gluconate at 0.12% |
|---|---|
| Sponsor | Universidad de Guanajuato |
| Drug class | Antimicrobial agent / Antiseptic |
| Target | Bacterial cell membrane |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Oral Health |
| Phase | Phase 3 |
Mechanism of action
Chlorhexidine is a cationic biguanide that binds to negatively charged bacterial cell membranes, causing leakage of cellular contents and protein denaturation. At the 0.12% concentration, it exhibits both bactericidal activity against gram-positive and gram-negative bacteria and some antifungal properties. It is commonly used as an oral rinse and topical antiseptic due to its broad-spectrum antimicrobial activity and low systemic absorption.
Approved indications
- Oral rinse for reduction of plaque and gingivitis
- Antimicrobial oral care in Phase 3 development
Common side effects
- Tooth staining
- Taste alteration
- Oral irritation
- Allergic contact dermatitis
Key clinical trials
- Dental Carotid Cognitive Study (NA)
- Baseline Oral Health Study: UnCoVer the Connections to General Health (PHASE4)
- Homemade Herbal Mouthwash in Gingivitis. A Randomized Clinical Trial. (PHASE3)
- Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-Growth (PHASE3)
- The Effect of Supplementary Foods Containing Trypsin, Chymotrypsin and Serratia Peptidase on Healing After Impacted Wisdom Tooth Surgery (NA)
- Comparison Of Clinical Effects Of Listerine And Chlorhexidine Mouth Wash In Patients Undergoing Fixed Orthodontic Treatment (NA)
- Clinical and Microbiological Comparison of 0.12% CHX and 0.05% CHX+0.05%CPC Mouthwashes in TPS Patients (NA)
- Comparison of 0.12% Chlorhexidine and MicroRepair ABX Mouthwash in Gingivitis Management (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Chlorhexidine gluconate at 0.12% CI brief — competitive landscape report
- Chlorhexidine gluconate at 0.12% updates RSS · CI watch RSS
- Universidad de Guanajuato portfolio CI