NCT03755362 is a NA clinical trial of Standard Treatment in Carotid Stenosis, sponsored by University of Maryland, Baltimore.

Who is sponsoring NCT03755362?

NCT03755362 is sponsored by University of Maryland, Baltimore.

What drugs are being tested in NCT03755362?

Interventions in NCT03755362: Standard Treatment, Intensive Treatment.

What condition does NCT03755362 study?

NCT03755362 studies Carotid Stenosis, Mild Cognitive Impairment, Periodontitis.

Is NCT03755362 still recruiting?

NCT03755362 is currently terminated. Last updated 18 February 2026.

Last reviewed 2026-02-18 · How we verify

NCT03755362

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Dental Carotid Cognitive Study

Terminated NA Last updated 18 February 2026

What this trial tests

NA trial testing Standard Treatment in Carotid Stenosis in 26 participants. Terminated before completion.

Timeline

8 April 2019

Primary endpoint
21 February 2021

25 February 2021

Quick facts

Lead sponsor	University of Maryland, Baltimore
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	26
Start date	8 April 2019
Primary completion	21 February 2021
Estimated completion	25 February 2021
Sites	1 location across United States

Drugs / interventions tested

Standard Treatment
Intensive Treatment — full drug profile →

Conditions studied

Carotid Stenosis — all drugs for Carotid Stenosis →
Mild Cognitive Impairment — all drugs for Mild Cognitive Impairment →
Periodontitis — all drugs for Periodontitis →

Sponsor

University of Maryland, Baltimore

Who can join

Adults 60 to 100, any sex, with Carotid Stenosis or Mild Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Periodontal Disease (PD) is present in 60+% of adults \>65 years and is associated with tobacco smoking, diabetes, and atherosclerosis that worsen inflammation, comorbidities common in older people with mild to moderate cognitive impairment (MCI). Older MCI patients are prone to poor oral hygiene and dental health, which if untreated worsens inflammation-mediated brain and nervous system function, and accelerates progression to dementia. Asymptomatic carotid artery stenosis (ACAS) is often a silent disease detected in only \~10% of older adults, and may have a strong association with MCI. This study examines the effects of intensive therapy for periodontitis on cognition in high-risk older people with ACAS. Results could highlight PD as a readily modifiable risk factor for dementia.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

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Trials testing the same drug.

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Other recruiting trials for Carotid Stenosis

Currently open trials in the same condition.

NCT07412249 — Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis · NA · recruiting
NCT07057297 — Residual Stenosis and Restenosis Following Carotid Endarterectomy With Primary Closure, A Prospective Tracking Study · recruiting
NCT06546761 — Selective Coronary Revascularization in Carotid Artery Disease Patients After Carotid Revascularization (SCORECAD Trial) · recruiting
NCT06986330 — Endovascular Treatment of Cerebrovascular Diseases Guided by Optical Coherence Tomography (OCT) Technology（CVD-OCT） · active not recruiting
NCT06485102 — Differences of the Postoperative Outcome for Carotid Surgery Patients Treated by Either Male or Female Surgeons · active not recruiting

Other University of Maryland, Baltimore trials

Trials by the same sponsor.

NCT07537413 — Ceftriaxone Dosage for Non-Critical Community-Acquired Pneumonia · Phase 4 · not yet recruiting
NCT07221799 — OER Glibenclamide for Neuropathic Pain in Multiple Sclerosis · Phase 1 · not yet recruiting
NCT07094672 — Development of an Opioid Withdrawal Clinical Outcome Assessment · not yet recruiting
NCT06583239 — Hub-Based Engagement Navigator Service to Reduce CSC Disengagement · NA · not yet recruiting
NCT07536412 — Decision Aid Efficacy in Low Risk Thyroid Cancer · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03755362 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Maryland, Baltimore
Last refreshed: 18 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03755362.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing