Bacterial 50S ribosomal subunit — Drug Target
All drugs that target Bacterial 50S ribosomal subunit — marketed and clinical-stage. Includes 5 drug classes acting on this target.
Drug classes
Oxazolidinone antibiotic · Macrolide antibiotic · Lincosamide antibiotic · Macrolide antibiotic / Streptogramin · Pleuromutilin antibiotic
Marketed (33)
- Oral Suspension Tedizolid Phosphate · Merck Sharp & Dohme LLC · Oxazolidinone antibiotic · Infectious Disease
Tedizolid phosphate is a prodrug that is converted to tedizolid, an oxazolidinone antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - QS azithromycin tablets · University of Taubate · Macrolide antibiotic · Infectious Disease
Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - IV azithromycin · Pfizer · Macrolide antibiotic · Infectious Disease
IV azithromycin is a macrolide antibiotic that binds to bacterial ribosomal RNA and inhibits protein synthesis, killing susceptible bacteria. - Clindamycin Gel (clindamycin ) · Stiefel, a GSK Company · Lincosamide antibiotic · Dermatology
Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - mass treatment with oral azithromycin · University of California, San Francisco · Macrolide antibiotic · Infectious Disease / Public Health
Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, and in mass treatment campaigns is used to reduce transmission of infectious diseases at the population level. - PRISTINAMYCIN XRP7263 · Sanofi · Macrolide antibiotic / Streptogramin · Infectious Disease
Pristinamycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Azithromycin Oral Product · Thomas Jefferson University · Macrolide antibiotic · Infectious Disease
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby stopping bacterial growth. - Azithromycin 1gm · Ain Shams Maternity Hospital · Macrolide antibiotic · Infectious Disease
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation and halting bacterial growth. - Clarithromycin (ST14) · National Taiwan University Hospital · Macrolide antibiotic · Infectious Disease
Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation and bacterial growth. - Topical Clindamycin · University of Toronto · Lincosamide antibiotic · Dermatology
Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Tedizolid PO · University of Southern California · Oxazolidinone antibiotic · Infectious Disease
Tedizolid inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation. - azithromycin (AZ) · Pfizer · Macrolide antibiotic · Infectious Disease
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation and stopping bacterial growth. - Intravenous Clarithromycin · University of Athens · Macrolide antibiotic · Infectious Disease
Clarithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Altabax (R) · St. Luke's-Roosevelt Hospital Center · Pleuromutilin antibiotic · Infectious Disease / Dermatology
Retapamulin is a bacterial protein synthesis inhibitor that binds to the bacterial ribosome to prevent bacterial growth. - P.O roxithromycin 150 mg*2/d for 7 days · Western Galilee Hospital-Nahariya · Macrolide antibiotic · Infectious Disease
Roxithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation and bacterial growth. - CLDM 1% gel · GlaxoSmithKline · Lincosamide antibiotic · Dermatology
Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Linezolid antimicrobial-lock solution · Clinica Universidad de Navarra, Universidad de Navarra · Oxazolidinone antibiotic · Infectious Disease
Linezolid inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation and bacterial growth. - Administration of Azithromycin on Day 1 · London School of Hygiene and Tropical Medicine · Macrolide antibiotic · Infectious Disease
Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Azithromycin 3 days · University of Oxford · Macrolide antibiotic · Infectious Disease
Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Clindamycin Topical Gel 1% · Jinnah Postgraduate Medical Centre · Lincosamide antibiotic · Dermatology
Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby reducing acne-causing bacteria and decreasing inflammation in acne lesions. - AzaSite Eye Drops · Merck Sharp & Dohme LLC · Macrolide antibiotic · Ophthalmology
AzaSite is an azithromycin ophthalmic suspension that reduces bacterial load and inflammatory mediators in the eye to treat bacterial conjunctivitis and meibomian gland dysfunction. - Zmax · Pfizer · Macrolide antibiotic · Infectious Disease
Zmax (azithromycin extended-release) is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Dalacin C · Oral and Maxillofacial Surgery Clinic, Poland · Lincosamide antibiotic · Infectious Disease
Dalacin C (clindamycin) inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation. - Azithromycin or placebo tablets · Rigshospitalet, Denmark · Macrolide antibiotic · Infectious Disease; Respiratory/Immunology (in investigational use)
Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Tedizolid IV · University of Southern California · Oxazolidinone antibiotic · Infectious Disease
Tedizolid inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation. - Retapamulin (Altabax) · The University of Texas Health Science Center, Houston · Pleuromutilin antibiotic · Infectious Disease / Dermatology
Retapamulin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing bacterial growth. - linezolid (Zyvox) · Pfizer · Oxazolidinone antibiotic · Infectious Disease
Linezolid inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation. - AzaSite® · Merck Sharp & Dohme LLC · Macrolide antibiotic · Ophthalmology
AzaSite is an azithromycin ophthalmic suspension that reduces bacterial load and inflammatory mediators in the eye to treat bacterial conjunctivitis and meibomian gland dysfunction. - FMS azithromycin tablets · University of Taubate · Macrolide antibiotic · Infectious Disease
Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Linezolid (L) · Shenzhen Third People's Hospital · Oxazolidinone antibiotic · Infectious Disease
Linezolid inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation. - Erythromycin, Azithromycin , Clarithromycin · Baqiyatallah Medical Sciences University · Macrolide antibiotic · Infectious Disease
These macrolide antibiotics inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit. - Azithromycin Ophthalmic Solution, 1% · Merck Sharp & Dohme LLC · Macrolide antibiotic · Ophthalmology / Infectious Disease
Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby killing or stopping the growth of susceptible bacteria. - Azithromycin 1 gram IV · Thomas Jefferson University · Macrolide antibiotic · Infectious Disease
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation and stopping bacterial growth.
Phase 3 pipeline (12)
- Clarithromycin DST (125 mg) · Grünenthal GmbH · Macrolide antibiotic · Infectious Disease
Clarithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Clarithromycin DST (250 mg) · Grünenthal GmbH · Macrolide antibiotic · Infectious Disease
Clarithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Retpamulin Ointment, 1% · Stiefel, a GSK Company · Pleuromutilin antibiotic · Infectious Disease / Dermatology
Retpamulin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation and bacterial growth. - Irrigation with Clindamycin solution · Hospital General Universitario Elche · Lincosamide antibiotic · Infectious Disease / Surgery
Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby reducing pathogenic bacterial growth in irrigated surgical or wound sites. - azithromycin (Zithromax) · Pfizer · Macrolide antibiotic · Infectious Disease
Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Clindamycin Phosphate Lotion 1% · Balmoral Medical company · Lincosamide antibiotic · Dermatology
Clindamycin phosphate inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, reducing acne-causing bacteria and inflammation on the skin. - clindamycin phosphate vaginal cream 2% · Actavis Inc. · Lincosamide antibiotic · Infectious Disease / Gynecology
Clindamycin phosphate is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby killing or inhibiting the growth of anaerobic bacteria and some gram-positive organisms responsible for bacterial vaginosis. - Clarithromycin DST (187.5 mg) · Grünenthal GmbH · Macrolide antibiotic · Infectious Disease
Clarithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. - Clarithromycin Syrup (125 mg) · Grünenthal GmbH · Macrolide antibiotic · Infectious Disease
Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation and bacterial growth. - Erythromycin Ointment · National Eye Institute (NEI) · Macrolide antibiotic · Ophthalmology / Infectious Disease
Erythromycin ointment is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, reducing bacterial growth and infection. - Azithromycin on Day 1 · Lihir Medical Centre · Macrolide antibiotic · Infectious Disease
Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide bond formation and halting bacterial growth. - CLDM 1% gel twice daily · GlaxoSmithKline · Lincosamide antibiotic · Dermatology
Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.