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Irrigation with Clindamycin solution
Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby reducing pathogenic bacterial growth in irrigated surgical or wound sites.
Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby reducing pathogenic bacterial growth in irrigated surgical or wound sites. Used for Surgical site infection prophylaxis via irrigation, Wound irrigation to reduce bacterial contamination.
At a glance
| Generic name | Irrigation with Clindamycin solution |
|---|---|
| Also known as | Irrigation of the surgical bed with Clindamycin solution |
| Sponsor | Hospital General Universitario Elche |
| Drug class | Lincosamide antibiotic |
| Target | Bacterial 50S ribosomal subunit |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Surgery |
| Phase | Phase 3 |
Mechanism of action
Clindamycin works by penetrating bacterial cells and binding to the bacterial 50S ribosomal subunit, which prevents peptide bond formation and halts protein synthesis. When used as an irrigation solution, it delivers high local antibiotic concentrations directly to the surgical or wound site, reducing bacterial colonization and infection risk. This topical/local delivery approach minimizes systemic exposure while maintaining effective antimicrobial activity against susceptible gram-positive and anaerobic organisms.
Approved indications
- Surgical site infection prophylaxis via irrigation
- Wound irrigation to reduce bacterial contamination
Common side effects
- Local irritation or inflammation at irrigation site
- Allergic reaction (rare, lincosamide hypersensitivity)
- Systemic absorption-related effects (uncommon with local irrigation)
Key clinical trials
- CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE) (PHASE4)
- Laparoscopic Antibiotic Lavage to Prevent Intra-abdominal Abscess Formation in Complicated Appendicitis (PHASE3)
- Reducing INfection at the Surgical SitE With Antibiotic Irrigation During Ventral Hernia Repair (RINSE Trial) (PHASE3)
- Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria (PHASE4)
- Antibiotic Irrigations for Intra-Abdominal Drains (PHASE2)
- Effect of a Combination of Bundles on Surgical-site Infection After Elective Colorectal Surgery (PHASE3)
- Effect of Peritoneal Lavage With Clindamycin-gentamicin on Laparoscopic Sleeve Gastrectomy (PHASE3)
- Effect of Peritoneal Lavage With Clindamycin-Gentamicin Solution & Oncologic Outcome (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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