{"id":"irrigation-with-clindamycin-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or inflammation at irrigation site"},{"rate":null,"effect":"Allergic reaction (rare, lincosamide hypersensitivity)"},{"rate":null,"effect":"Systemic absorption-related effects (uncommon with local irrigation)"}]},"_chembl":{"chemblId":"CHEMBL1200588","moleculeType":"Small molecule","molecularWeight":"461.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clindamycin works by penetrating bacterial cells and binding to the bacterial 50S ribosomal subunit, which prevents peptide bond formation and halts protein synthesis. When used as an irrigation solution, it delivers high local antibiotic concentrations directly to the surgical or wound site, reducing bacterial colonization and infection risk. This topical/local delivery approach minimizes systemic exposure while maintaining effective antimicrobial activity against susceptible gram-positive and anaerobic organisms.","oneSentence":"Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby reducing pathogenic bacterial growth in irrigated surgical or wound sites.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:15.014Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Surgical site infection prophylaxis via irrigation"},{"name":"Wound irrigation to reduce bacterial contamination"}]},"trialDetails":[{"nctId":"NCT05846399","phase":"PHASE4","title":"CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE)","status":"RECRUITING","sponsor":"University of Missouri-Columbia","startDate":"2023-09-07","conditions":"Cat Bite, Hand Injuries, Arm Injury","enrollment":72},{"nctId":"NCT06841003","phase":"PHASE3","title":"Laparoscopic Antibiotic Lavage to Prevent Intra-abdominal Abscess Formation in Complicated Appendicitis","status":"NOT_YET_RECRUITING","sponsor":"Spaarne Gasthuis","startDate":"2025-02","conditions":"Complicated Appendicitis, Intra-Abdominal Abscess","enrollment":752},{"nctId":"NCT03945357","phase":"PHASE3","title":"Reducing INfection at the Surgical SitE With Antibiotic Irrigation During Ventral Hernia Repair (RINSE Trial)","status":"COMPLETED","sponsor":"Prisma Health-Upstate","startDate":"2019-05-15","conditions":"Ventral Hernia Repair","enrollment":250},{"nctId":"NCT04035070","phase":"PHASE4","title":"Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2021-01","conditions":"Necrotic Pulp","enrollment":51},{"nctId":"NCT03476941","phase":"PHASE2","title":"Antibiotic Irrigations for Intra-Abdominal Drains","status":"RECRUITING","sponsor":"Paolo Goffredo","startDate":"2019-04-01","conditions":"Abdominal Abscess","enrollment":50},{"nctId":"NCT03081962","phase":"PHASE3","title":"Effect of a Combination of Bundles on Surgical-site Infection After Elective Colorectal Surgery","status":"UNKNOWN","sponsor":"Hospital General Universitario Elche","startDate":"2017-02-15","conditions":"Surgical Site Infection","enrollment":102},{"nctId":"NCT02479971","phase":"PHASE3","title":"Effect of Peritoneal Lavage With Clindamycin-gentamicin on Laparoscopic Sleeve Gastrectomy","status":"COMPLETED","sponsor":"Hospital General Universitario Elche","startDate":"2014-01","conditions":"Pain","enrollment":60},{"nctId":"NCT02399059","phase":"PHASE3","title":"Effect of Peritoneal Lavage With Clindamycin-Gentamicin Solution & Oncologic Outcome","status":"COMPLETED","sponsor":"Hospital General Universitario Elche","startDate":"2011-01","conditions":"Colorectal Tumors","enrollment":106},{"nctId":"NCT02314806","phase":"PHASE3","title":"Gentamicin Versus Clindamycin Versus Normal Saline Lavage in Axilla","status":"COMPLETED","sponsor":"Hospital General Universitario Elche","startDate":"2013-01","conditions":"Breast Cancer","enrollment":51},{"nctId":"NCT01378832","phase":"PHASE3","title":"Effect of Peritoneal Lavage With Clindamycin-gentamicin Solution on Postoperative Colorectal Cancer Infection in Elective Surgery","status":"COMPLETED","sponsor":"Universidad Miguel Hernandez de Elche","startDate":"2010-01","conditions":"Surgical Site Infection","enrollment":102}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Irrigation of the surgical bed with Clindamycin solution"],"phase":"phase_3","status":"active","brandName":"Irrigation with Clindamycin solution","genericName":"Irrigation with Clindamycin solution","companyName":"Hospital General Universitario Elche","companyId":"hospital-general-universitario-elche","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clindamycin is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby reducing pathogenic bacterial growth in irrigated surgical or wound sites. Used for Surgical site infection prophylaxis via irrigation, Wound irrigation to reduce bacterial contamination.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}