Alpha-1A adrenergic receptor — Drug Target

All drugs that target Alpha-1A adrenergic receptor — marketed and clinical-stage. Includes 14 drug classes acting on this target.

Drug classes

guanethidine · guanadrel · Alpha-1A adrenergic antagonist · dexmedetomidine · methoxamine · Alpha-1A adrenergic receptor antagonist · Sympathomimetic Amine Anorectic · Indirectly Acting Sympathomimetic Amines · alpha-Adrenergic Blocker · thiethylperazine · maprotiline · Alpha-1A adrenergic receptor antagonist (active comparator: tamsulosin)

Marketed (13)

• Ismelin · guanethidine · Neuroscience
• Hylorel · Pfizer · guanadrel · Cardiovascular
• Tamsulosin Hydrochloride 0.4 milligrams · Pontificia Universidad Catolica de Chile · Alpha-1A adrenergic antagonist · Urology
  Tamsulosin selectively blocks alpha-1A adrenergic receptors in the prostate and bladder neck, relaxing smooth muscle to improve urine flow.
• Dexmedetomidine Hydrochloride · Pfizer · dexmedetomidine · Cardiovascular
  Dexmedetomidine Hydrochloride is a relatively selective centrally acting alpha 2 -adrenergic agonist with sedative properties.
• Methoxamin · GSK · methoxamine · Cardiovascular
• Tamsulosine Arrow LP · Pierre Fabre Medicament · Alpha-1A adrenergic receptor antagonist · Urology
  Tamsulosin is an alpha-1A adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow.
• Didrex · Pfizer · Sympathomimetic Amine Anorectic · Metabolic
• Vialin · Baxter · Indirectly Acting Sympathomimetic Amines · Hematology
• Minipress · Pfizer · alpha-Adrenergic Blocker · Cardiovascular
• Ethylthioperazine · Novartis · thiethylperazine · Pain
• MAPROTILINE · maprotiline · Neuroscience
• Placebo matching Tamsulosine LP · Pierre Fabre Medicament · Alpha-1A adrenergic receptor antagonist (active comparator: tamsulosin) · Urology
  This is a placebo formulation designed to match the appearance and administration profile of Tamsulosin LP (long-acting tamsulosin) for use in clinical trials.
• Tamsulosin BID · Gundersen Lutheran Medical Foundation · Alpha-1A adrenergic receptor antagonist · Urology
  Tamsulosin is an alpha-1A adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow.

Phase 3 pipeline (6)

• Disintegrating placebo tamsulosin tablet · GlaxoSmithKline · Alpha-1A adrenergic receptor antagonist · Urology
  Tamsulosin is an alpha-1A adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow.
• Preventive administration of Rapaflo · Sir Mortimer B. Davis - Jewish General Hospital · Alpha-1A adrenergic receptor antagonist · Urology
  Rapaflo (silodosin) is an alpha-1A adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow.
• Omnic Ocas · EMS · Alpha-1A adrenergic receptor antagonist · Urology
  Omnic Ocas is a once-daily oral formulation of tamsulosin that selectively blocks alpha-1A adrenergic receptors in the prostate and bladder neck to relieve urinary obstruction.
• RVL-1201 · RVL Pharmaceuticals, Inc. · Alpha-1A adrenergic agonist · Ophthalmology
  RVL-1201 is an alpha-1A adrenergic agonist that increases pupil dilation (mydriasis) by stimulating alpha-1A receptors on the dilator pupillae muscle.
• Detantol · bunazosin · Cardiovascular
  Detanidol works by blocking the alpha-1A adrenergic receptor, which helps to relax blood vessels and lower blood pressure.
• Uroxatrol (drug) · New York Prostate Institute · Alpha-1A adrenergic receptor antagonist · Urology
  Uroxatrol is an alpha-1A adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow.