What is Hylorel used for?

Hylorel is indicated for Hypertensive disorder.

Hylorel is developed by Pfizer.

What development phase is Hylorel in?

Hylorel is FDA-approved (marketed).

What is the generic name of Hylorel?

GUANADREL is the generic (nonproprietary) name of Hylorel.

Last reviewed 2026-04-20 · How we verify

Hylorel (GUANADREL)

Pfizer · FDA-approved approved Small molecule Quality 25/100

Hylorel (Guanadrel) is a small molecule drug developed by Pharmacia and Upjohn that targets the alpha-1A adrenergic receptor. It is classified as a guanadrel and was FDA approved in 1982 for the treatment of hypertensive disorders. As an off-patent medication, there are currently no generic manufacturers. Key safety considerations include its potential effects on blood pressure and heart rate. Hylorel is a vasodilator that works by blocking the alpha-1A adrenergic receptor, leading to decreased peripheral resistance and lowered blood pressure.

At a glance

Generic name	GUANADREL
Sponsor	Pfizer
Drug class	guanadrel
Target	Alpha-1A adrenergic receptor
Modality	Small molecule
Therapeutic area	Cardiovascular
Phase	FDA-approved
First approval	1982

Approved indications

Hypertensive disorder

Common side effects

No common side effects on file.

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
FDA label	Mechanism, indications, dosing, boxed warnings, drug interactions