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Levobupivacaine without epinephrine
Levobupivacaine without epinephrine is a Local anesthetic (amide) Small molecule drug developed by Pontificia Universidad Catolica de Chile. It is currently FDA-approved for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.
Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.
At a glance
| Generic name | Levobupivacaine without epinephrine |
|---|---|
| Sponsor | Pontificia Universidad Catolica de Chile |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Levobupivacaine is the S-enantiomer of bupivacaine, a long-acting amide local anesthetic. It reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and transmission of nerve impulses. The absence of epinephrine means this formulation lacks vasoconstrictive properties and relies solely on the anesthetic's intrinsic duration of action.
Approved indications
- Local and regional anesthesia for surgical procedures
- Infiltration anesthesia
- Nerve blocks
- Epidural anesthesia
Common side effects
- Injection site reactions (pain, erythema)
- Transient neurological symptoms
- Hypotension
- Bradycardia
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- Ultrasound-Guided Quadro-Iliac Plane Block for Pain Management After Total Hip Arthroplasty (NA)
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
- PK/PD Levobupivacaine with and Without Epinephrine After Ultrasound Guided ESP Block (PHASE4)
- Efficacy of Adrenaline in Periarticular Analgesic Injection on Postoperative Pain Control After Total Knee Arthroplasty (PHASE2)
- Plasma Concentrations of Levobupivacaine With and Without Epinephrine in Transversus Abdominis Plane Blocks (PHASE4)
- The Analgesic Efficacy of Local Anaesthetic Wound Infiltration Versus Intrathecal Morphine for Total Knee Replacement (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Levobupivacaine without epinephrine CI brief — competitive landscape report
- Levobupivacaine without epinephrine updates RSS · CI watch RSS
- Pontificia Universidad Catolica de Chile portfolio CI
Frequently asked questions about Levobupivacaine without epinephrine
What is Levobupivacaine without epinephrine?
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Related
- Drug class: All Local anesthetic (amide) drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: Pontificia Universidad Catolica de Chile — full pipeline
- Therapeutic area: All drugs in Anesthesia
- Indication: Drugs for Local and regional anesthesia for surgical procedures
- Indication: Drugs for Infiltration anesthesia
- Indication: Drugs for Nerve blocks
- Compare: Levobupivacaine without epinephrine vs similar drugs
- Pricing: Levobupivacaine without epinephrine cost, discount & access