Levobupivacaine without epinephrine — Competitive Intelligence Brief

Levobupivacaine without epinephrine (Levobupivacaine without epinephrine) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic (amide). Area: Anesthesia.

marketed Local anesthetic (amide) Voltage-gated sodium channels Anesthesia Small molecule

Target snapshot

Levobupivacaine without epinephrine (Levobupivacaine without epinephrine) — Pontificia Universidad Catolica de Chile. Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Levobupivacaine without epinephrine TARGET	Levobupivacaine without epinephrine	Pontificia Universidad Catolica de Chile	marketed	Local anesthetic (amide)	Voltage-gated sodium channels
Buffered Articaine Hydrochloride + Epinephrine	Buffered Articaine Hydrochloride + Epinephrine	Ohio State University	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component)
Naropeine (Ropivacaine)	Naropeine (Ropivacaine)	Nantes University Hospital	marketed	Local anesthetic (amide)	Voltage-gated sodium channels
Synera(TM)	Synera(TM)	IWK Health Centre	marketed	Topical local anesthetic	Voltage-gated sodium channels
Lidocaine / propofol admixture	Lidocaine / propofol admixture	Benaroya Research Institute	marketed	Local anesthetic / sedative combination	Voltage-gated sodium channels (lidocaine); GABA-A receptor (propofol)
Articaine Hydrochloride + Epinephrine	Articaine Hydrochloride + Epinephrine	Ankara Yildirim Beyazıt University	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component)
Lidocaine aerosol 2.4% topical	Lidocaine aerosol 2.4% topical	Jiangang Song	marketed	Local anesthetic	Voltage-gated sodium channels

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic (amide) class)

1. Poznan University of Medical Sciences · 4 drugs in this class
2. Nantes University Hospital · 3 drugs in this class
3. Bozyaka Training and Research Hospital · 2 drugs in this class
4. ASST Gaetano Pini-CTO · 2 drugs in this class
5. Centre Hospitalier Universitaire de Nīmes · 1 drug in this class
6. Chiang Mai University · 1 drug in this class
7. Beijing Tiantan Hospital · 1 drug in this class
8. Complejo Hospitalario Universitario de Granada · 1 drug in this class
9. Ciusss de L'Est de l'Île de Montréal · 1 drug in this class
10. China Medical University, China · 1 drug in this class