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A Comparison of the Analgesic Efficacy of Local Anaesthetic Wound Infiltration Versus Intrathecal Morphine for Total Knee Replacement
Total knee replacement (TKR) is associated postoperatively with considerable pain and analgesic requirement. Total knee replacement is routinely performed under spinal anaesthesia with intrathecal bupivacaine plus preservative free morphine. We hypothesize that infiltration of the surgical site with peri- and intraarticular levobupivacaine local anaesthetic would be an efficacious pain management technique and would not be inferior to intrathecal morphine for postoperative pain management. We further hypothesize that the use of this surgical site infiltration technique would decrease post-operative systemic opioid requirements as well as the side effects associated with intrathecal and systemic opioids.
Details
| Lead sponsor | Cork University Hospital |
|---|---|
| Phase | Phase 4 |
| Status | UNKNOWN |
| Enrolment | 42 |
| Start date | 2010-08 |
| Completion | 2011-06 |
Conditions
- Total Knee Replacement
Interventions
- Levobupivacaine
- Intrathecal morphine
Primary outcomes
- Quality of analgesia in the postoperative period as assessed by visual analogue score (VAS) for pain at rest and on movement — 24 hours postoperatively
Countries
Ireland