Last reviewed · How we verify
Intra thecal morphine.
Intra thecal morphine. is a Opioid agonist Small molecule drug developed by Ain Shams University. It is currently FDA-approved for Chronic pain management, Cancer pain, Post-operative pain.
Intrathecal morphine is an opioid agonist that binds to mu opioid receptors in the spinal cord to block pain signal transmission.
Intra thecal morphine is used to treat postoperative pain, particularly after total hip arthroplasty and total abdominal hysterectomy. It is administered directly into the spinal canal, where it acts to reduce pain.
At a glance
| Generic name | Intra thecal morphine. |
|---|---|
| Sponsor | Ain Shams University |
| Drug class | Opioid agonist |
| Target | Mu opioid receptor (μ-opioid receptor) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Morphine delivered directly into the cerebrospinal fluid via intrathecal injection achieves high local concentrations at spinal opioid receptors while minimizing systemic exposure. This direct spinal delivery produces potent analgesia by inhibiting pain neurotransmitter release and blocking nociceptive signal propagation at the dorsal horn of the spinal cord.
Approved indications
- Chronic pain management
- Cancer pain
- Post-operative pain
- Intractable pain unresponsive to systemic opioids
Common side effects
- Respiratory depression
- Pruritus
- Nausea and vomiting
- Urinary retention
- Hypotension
- Headache
Key clinical trials
- Ultrasound Guided Erector Spinae Plane Block vs Intrathecal Morphine (PHASE4)
- PENG Block vs Supra-inguinal Fascia Iliaca Compartment Block for Postoperative Opioids Consumption and Early Motor Recovery After THA: a Randomized Controlled Non-inferiority Clinical Trial. (PHASE4)
- Study to Examine Pain Relief With Supplemental Intrathecal Morphine in TKA Patients (PHASE4)
- Intrathecal Morphine in Knee Arthroplasty (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intra thecal morphine. CI brief — competitive landscape report
- Intra thecal morphine. updates RSS · CI watch RSS
- Ain Shams University portfolio CI
Frequently asked questions about Intra thecal morphine.
What is Intra thecal morphine.?
How does Intra thecal morphine. work?
What is Intra thecal morphine. used for?
Who makes Intra thecal morphine.?
What drug class is Intra thecal morphine. in?
What development phase is Intra thecal morphine. in?
What are the side effects of Intra thecal morphine.?
What does Intra thecal morphine. target?
Related
- Drug class: All Opioid agonist drugs
- Target: All drugs targeting Mu opioid receptor (μ-opioid receptor)
- Manufacturer: Ain Shams University — full pipeline
- Therapeutic area: All drugs in Pain Management
- Indication: Drugs for Chronic pain management
- Indication: Drugs for Cancer pain
- Indication: Drugs for Post-operative pain
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing