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NCT00695045
Determination of the Efficacy and Side-Effect Profile of Lower Doses of Intrathecal Morphine in Patients Undergoing Total Knee Arthroplasty
NA trial testing intra thecal morphine in Pain, Postoperative in 60 participants. Completed in 1 April 2007.
1 January 2007
Quick facts
| Lead sponsor | University College Hospital Galway |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 1 July 2003 |
| Primary completion | 1 January 2007 |
| Estimated completion | 1 April 2007 |
Drugs / interventions tested
- intra thecal morphine
- intra thecal morphine
- intra thecal morphine
Conditions studied
- Pain, Postoperative — all drugs for Pain, Postoperative →
- Arthroplasty, Replacement, Knee — all drugs for Arthroplasty, Replacement, Knee →
Sponsor
University College Hospital Galway
Who can join
18 and older, any sex, with Pain, Postoperative or Arthroplasty, Replacement, Knee. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
pain
Time frame: 24 hours
Sponsor's own description
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement.We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Determination Of The Efficacy And Side-effect Profile Of Lower Doses Of Intrathecal Morphine In Patients Undergoing Total Knee Arthroplasty.
Hassett P, Ansari B, Gnanamoorthy P, Kinirons B, et al · · 2008 · cited 15× · PMID 18816386 · DOI 10.1186/1471-2253-8-5
Verify or expand the search:
- PubMed search for NCT00695045
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University College Hospital Galway trials
Trials by the same sponsor.
- NCT07453498 — Evaluating the Efficacy of the Psoas Sheath Block for Post Operative Analgesia Following Hip Arthroplasty · NA · recruiting
- NCT06419153 — Evaluating the Efficacy of the Sub-psoas Fascial Plane Block for Post-operative Analgesia Following Hemiarthroplasty · not yet recruiting
- NCT05839704 — A Comparison of Two Regional Techniques for Bariatric Sleeve Gastrectomy · NA · unknown
- NCT05804565 — MetaMet: Bone Cutter Versus Bone Saw for Ray Amputation · NA · unknown
- NCT05124093 — The Effect of High-flow Nasal Oxygen Flow Rate on Gas Exchange During Apnoea · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00695045 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University College Hospital Galway
- Last refreshed: 9 June 2008
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00695045.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing