NCT02620631 is a Phase 4 clinical trial of Morphine in Acute Pain, sponsored by Stony Brook University.

Who is sponsoring NCT02620631?

NCT02620631 is sponsored by Stony Brook University.

What drugs are being tested in NCT02620631?

Interventions in NCT02620631: Morphine, Placebo.

What condition does NCT02620631 study?

NCT02620631 studies Acute Pain.

Is NCT02620631 still recruiting?

NCT02620631 is currently status unknown. Last updated 1 December 2015.

Last reviewed 2015-12-01 · How we verify

NCT02620631

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Prospective, Randomized, Double-blinded, Placebo-controlled Study to Examine Pain Relief and the Need for Supplementary Analgesics With Intra-thecal Morphine Sulfate (0.2 mg) in Patients Undergoing Total Knee Arthroplasty (TKA)

Status unknown Phase 4 Last updated 1 December 2015

What this trial tests

Phase 4 trial testing Morphine in Acute Pain in 54 participants. Status unknown.

Timeline

1 March 2011

Primary endpoint
1 February 2014

1 January 2017

Quick facts

Lead sponsor	Stony Brook University
Phase	Phase 4
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Enrollment	54
Start date	1 March 2011
Primary completion	1 February 2014
Estimated completion	1 January 2017
Sites	1 location across United States

Drugs / interventions tested

Morphine
Placebo

Conditions studied

Acute Pain — all drugs for Acute Pain →

Sponsor

Stony Brook University

Who can join

Adults 18 to 80, any sex, with Acute Pain. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Acute pain at rest
Time frame: 0-24 hours
Numerical rating scale pain scores were collected every 4 hours

Sponsor's own description

This is a prospective, randomized, double-blinded, placebo-controlled study designed to examine pain relief following intrathecal morphine sulfate (0.2mg) in patients undergoing total knee arthroplasty (TKA) under spinal anesthesia in addition to a femoral nerve catheter. The protocol consists of two parts: (1) a prospective patient recruitment study and (2) a retrospective assay for endocannabinoids on previously collected specimens.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Intrathecal morphine administration reduces postoperative pain and peripheral endocannabinoid levels in total knee arthroplasty patients: a randomized clinical trial.
Kaczocha M, Azim S, Nicholson J, Rebecchi MJ, et al · · 2018 · cited 17× · PMID 29486720 · DOI 10.1186/s12871-018-0489-5

Verify or expand the search:

Other trials of Morphine

Trials testing the same drug.

NCT06315920 — Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department · Phase 3 · not yet recruiting
NCT07491146 — Phase II Clinical Study of the Efficacy and Safety of HSK55718 in the Treatment of Abdominal Postoperative Pain · Phase 2 · not yet recruiting
NCT07412223 — Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery · Phase 4 · not yet recruiting
NCT07246785 — Anrikefon-based Patient-controlled Intravenous Analgesia After Laparoscopic Surgery · Phase 4 · terminated
NCT07201272 — Transversalis Fascia Plane Block Versus Intrathecal Morphine for Postoperative Analgesia in Total Abdominal Hysterectomy · NA · recruiting

Other recruiting trials for Acute Pain

Currently open trials in the same condition.

NCT06779604 — Dexmedetomidine and Dexamethasone Added as Adjuvant Infraclavicular Brachial Plexus Block in Upper Limb Surgery · recruiting
NCT07348419 — Quadro-Iliac vs Thoracolumbar Interfascial Plane Block for Analgesia After Single-Level Lumbar Disc Surgery · NA · recruiting
NCT07335159 — Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention · NA · recruiting
NCT07348523 — Comparison of the Postoperative Analgesic Efficacy of Classical and Modified Erector Spinae Plane Blocks After Lumbar Sp · NA · recruiting
NCT07336264 — Characterization of Acute Pain · recruiting

Other Stony Brook University trials

Trials by the same sponsor.

NCT07478250 — First Responder Safety Training (FiRST) · NA · not yet recruiting
NCT07076342 — The Role of mGluR5 in CBT-I · Phase 4 · recruiting
NCT07009691 — Hydrogen Water Intervention With Heart Rate Variability as an Outcome Biomarker in ME/CFS · NA · recruiting
NCT07114900 — Randomized Controlled Physical Activity App Intervention for Black Women · Phase 3 · active not recruiting
NCT05245227 — Double Simultaneous Uterotonic Agents Versus Single Agent Regimen to Prevent Early Postpartum Hemorrhage · Phase 3 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02620631 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Stony Brook University
Last refreshed: 1 December 2015

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02620631.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing