{"id":"intra-thecal-morphine","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Morphine delivered directly into the cerebrospinal fluid via intrathecal injection achieves high local concentrations at spinal opioid receptors while minimizing systemic exposure. This direct spinal delivery produces potent analgesia by inhibiting pain neurotransmitter release and blocking nociceptive signal propagation at the dorsal horn of the spinal cord.","oneSentence":"Intrathecal morphine is an opioid agonist that binds to mu opioid receptors in the spinal cord to block pain signal transmission.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:49:31.750Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic pain management"},{"name":"Cancer pain"},{"name":"Post-operative pain"},{"name":"Intractable pain unresponsive to systemic opioids"}]},"trialDetails":[{"nctId":"NCT05218733","phase":"PHASE4","title":"Ultrasound Guided Erector Spinae Plane Block vs Intrathecal Morphine","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2022-02-15","conditions":"Post Operative Pain","enrollment":120},{"nctId":"NCT04690023","phase":"PHASE4","title":"PENG Block vs Supra-inguinal Fascia Iliaca Compartment Block for Postoperative Opioids Consumption and Early Motor Recovery After THA: a Randomized Controlled Non-inferiority Clinical Trial.","status":"UNKNOWN","sponsor":"University of Liege","startDate":"2022-01-01","conditions":"Total Hip Arthroplasty","enrollment":82},{"nctId":"NCT02620631","phase":"PHASE4","title":"Study to Examine Pain Relief With Supplemental Intrathecal Morphine in TKA Patients","status":"UNKNOWN","sponsor":"Stony Brook University","startDate":"2011-03","conditions":"Acute Pain","enrollment":54},{"nctId":"NCT00695045","phase":"NA","title":"Intrathecal Morphine in Knee Arthroplasty","status":"COMPLETED","sponsor":"University College Hospital Galway","startDate":"2003-07","conditions":"Pain, Postoperative, Arthroplasty, Replacement, Knee","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Intra thecal morphine.","genericName":"Intra thecal morphine.","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intra thecal morphine is used to treat postoperative pain, particularly after total hip arthroplasty and total abdominal hysterectomy. It is administered directly into the spinal canal, where it acts to reduce pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}