Atomoxetine (ATO) · Psychiatry / Neurology Atomoxetine selectively inhibits the reuptake of norepinephrine in the central nervous system, increasing norepinephrine availability at synapses.
Intravenous Esketamine · Psychiatry / Mental Health Intravenous esketamine is an NMDA receptor antagonist that rapidly blocks glutamate signaling in the brain to produce fast-acting antidepressant effects.
Treatment C (placebo) Placebo has no active pharmacological mechanism; it produces therapeutic effects through psychological and physiological expectation.
VEN · Oncology Venetoclax is a selective inhibitor of the anti-apoptotic protein BCL-2 that promotes cancer cell death by restoring apoptosis.
Phase 3 pipeline
5-Flurouracil · Oncology 5-Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase and gets incorporated into RNA and DNA, disrupting nucleotide synthesis and causing cell death.
Abiraterone Acetate (AA) · Oncology Abiraterone acetate inhibits CYP17A1, a key enzyme in androgen synthesis, thereby reducing testosterone production in patients with castration-resistant prostate cancer.
Abiraterone acetate and prednisone · Oncology Abiraterone acetate inhibits CYP17A1 to block androgen synthesis, while prednisone suppresses ACTH-driven compensatory steroid production in castration-resistant prostate cancer.
Amivantamab Intravenous · Oncology Amivantamab is a bispecific monoclonal antibody that simultaneously binds to EGFR and MET receptors, blocking their signaling and triggering immune-mediated tumor cell death.
Antihyperglycemic agent(s) · Endocrinology / Diabetes Antihyperglycemic agents work by reducing blood glucose levels through various mechanisms such as enhancing insulin secretion, improving insulin sensitivity, or reducing hepatic glucose production.
BCG Vesiculture · Oncology BCG Vesiculture is a live attenuated Bacillus Calmette-Guérin vaccine formulation designed to stimulate innate and adaptive immune responses against bladder cancer.
Best Supportive Care (BSC) Best Supportive Care (BSC) is a control or comparator arm in clinical trials that provides standard medical management and symptom relief without the investigational drug.
Dapoxetine hydrochloride · Urology / Sexual Health Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that increases serotonin levels in the central nervous system to delay ejaculation.
Dara IV · Oncology Daratumumab is a monoclonal antibody that binds to CD38 on the surface of multiple myeloma cells, triggering their destruction through multiple immune mechanisms.
Dara SC · Oncology Dara SC (daratumumab subcutaneous) is a monoclonal antibody that targets CD38 on multiple myeloma cells, triggering their destruction through multiple immune mechanisms.
Daratumumab IV · Oncology Daratumumab is a monoclonal antibody that binds to CD38 on the surface of multiple myeloma cells, triggering their destruction through multiple immune mechanisms.
Daratumumab SC · Oncology Daratumumab is a monoclonal antibody that binds to CD38 on multiple myeloma cells, triggering their destruction through multiple immune mechanisms.
Daratumumab SC: daratumumab + rHuPH20 · Oncology Daratumumab is a monoclonal antibody that binds to CD38 on multiple myeloma cells and triggers their destruction through multiple immune mechanisms, while rHuPH20 enhances subcutaneous bioavailability.
DRV/COBI FDC · Infectious Disease DRV/COBI is a fixed-dose combination of darunavir (a protease inhibitor) and cobicistat (a pharmacokinetic booster) that inhibits HIV protease to prevent viral replication.
epoetin alfa + packed RBC transfusion · Oncology Epoetin alfa stimulates erythropoiesis by binding to the erythropoietin receptor, promoting the production of red blood cells.
ExPEC9V · Immunology / Infectious Disease ExPEC9V is a vaccine designed to stimulate immune responses against extraintestinal pathogenic E. coli (ExPEC) strains.
Genetic: AAV5-hRKp.RPGR · Ophthalmology / Rare Genetic Disorders AAV5-hRKp.RPGR is a gene therapy that delivers a functional copy of the RPGR gene into retinal cells to restore vision in patients with X-linked retinitis pigmentosa.
Genetic: AAV5-hRKp.RPGR Intermediate Dose · Ophthalmology / Retinal Diseases AAV5-hRKp.RPGR is a gene therapy that delivers a functional copy of the RPGR gene into retinal cells to restore vision in patients with X-linked retinitis pigmentosa.
Genetic: AAV5-hRKp.RPGR Low Dose · Ophthalmology / Retinal Genetic Disorders AAV5-hRKp.RPGR is a gene therapy that delivers a functional copy of the RPGR gene into retinal cells to restore vision in patients with X-linked retinitis pigmentosa.
Guselkumab Dose 1 · Immunology/Dermatology Guselkumab is a monoclonal antibody that selectively blocks interleukin-23 (IL-23) signaling to reduce inflammatory immune responses.
Guselkumab Subcutaneous · Immunology / Dermatology Guselkumab is a monoclonal antibody that selectively blocks interleukin-23 (IL-23) signaling to reduce inflammatory immune responses.
HD quadrivalent influenza vaccine · Immunology / Infectious Disease HD quadrivalent influenza vaccine stimulates immune responses against four strains of influenza virus using a high-dose antigen formulation to enhance protection, particularly in older adults.
JNJ-77242113 · Neurology/Psychiatry JNJ-77242113 is a selective inhibitor of phosphodiesterase 10A (PDE10A) that increases intracellular signaling in the brain to modulate neuronal activity.
JNJ-79635322 · Immunology JNJ-79635322 is a monoclonal antibody that targets and inhibits IL-17A, a pro-inflammatory cytokine involved in immune-mediated inflammatory diseases.
Leucovorin calcium/Levoleucovorin · Oncology Leucovorin calcium and levoleucovorin are reduced folate cofactors that enhance the efficacy of antimetabolite chemotherapy agents by providing essential one-carbon units for nucleotide synthesis.
Matching Placebo to JNJ-77242113 This is a placebo control formulation matching the inactive vehicle and appearance of JNJ-77242113 for blinded clinical trial comparison.
Matching placebo to Quetiapine XR · Psychiatry This is a matching placebo formulation designed to mimic Quetiapine XR (an atypical antipsychotic) for blinded clinical trial purposes.
Matching placebo to Seltorexant · Neurology This is a matching placebo control formulation designed to mimic Seltorexant, an orexin 2 receptor antagonist used in sleep disorder trials.
Matching Placebo to Ustekinumab This is a placebo formulation designed to match the appearance and administration route of ustekinumab for blinded clinical trial comparison.
Metformin immediate release · Diabetes Metformin reduces hepatic glucose production and improves insulin sensitivity by activating AMP-activated protein kinase (AMPK) and inhibiting mitochondrial complex I.
Nipocalimab SC-LIV · Immunology Nipocalimab is a subcutaneous monoclonal antibody that blocks neonatal Fc receptor (FcRn) to reduce pathogenic immunoglobulin levels in autoimmune conditions.
PCI-32765 (Ibrutinib) · Oncology Ibrutinib is a small-molecule inhibitor of Bruton's tyrosine kinase (BTK) that blocks B-cell receptor signaling and reduces proliferation of malignant B cells.
Placebo (20% Intralipid) Placebo (20% Intralipid) does not have an active pharmacological effect; it serves as a control in clinical trials.
Placebo and prednisone · Immunology This is a comparator arm combining placebo with prednisone, a corticosteroid that suppresses immune function and reduces inflammation.
Placebo for guselkumab A placebo contains no active pharmaceutical ingredient and produces no direct pharmacological effect.
Placebo for Niraparib · Oncology A placebo contains no active pharmaceutical ingredient and produces no direct pharmacological effect.
PP1M · Neurology/Psychiatry PP1M is a phosphodiesterase 10 (PDE10) inhibitor that increases intracellular cyclic nucleotide levels to modulate neuronal signaling.
PP6M injection Dose 1 · Contraception / Women's Health PP6M is a long-acting injectable contraceptive that prevents pregnancy through hormonal suppression of ovulation.
Phase 2 pipeline
AAV5-hRKp.RPGR · Ophthalmology AAV5-hRKp.RPGR is a gene therapy that delivers a functional copy of the RPGR gene into retinal cells to restore vision in patients with X-linked retinitis pigmentosa.
Bermekimab Monoclonal Antibody · Immunology Bermekimab is a monoclonal antibody that blocks IL-1β, a key pro-inflammatory cytokine, to reduce inflammation and immune activation.