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Matching placebo to Seltorexant
Matching placebo to Seltorexant is a Small molecule drug developed by Janssen Research & Development, LLC. It is currently in Phase 3 development for Matching placebo control for Seltorexant clinical trials (not a therapeutic agent).
This is a matching placebo control formulation designed to mimic Seltorexant, an orexin 2 receptor antagonist used in sleep disorder trials.
This is a matching placebo control formulation designed to mimic Seltorexant, an orexin 2 receptor antagonist used in sleep disorder trials. Used for Matching placebo control for Seltorexant clinical trials (not a therapeutic agent).
At a glance
| Generic name | Matching placebo to Seltorexant |
|---|---|
| Sponsor | Janssen Research & Development, LLC |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | Phase 3 |
Mechanism of action
Seltorexant is an orexin 2 receptor antagonist that promotes sleep by blocking orexin signaling in the central nervous system. The matching placebo is an inert formulation manufactured to be indistinguishable from the active drug in appearance, taste, and administration to maintain blinding in clinical trials. This placebo serves as the control arm in Phase 3 studies evaluating Seltorexant's efficacy and safety in insomnia.
Approved indications
- Matching placebo control for Seltorexant clinical trials (not a therapeutic agent)
Common side effects
Key clinical trials
- Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms (PHASE3)
- A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy (PHASE3)
- A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy (PHASE3)
- A Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42847922 in Participants With Insomnia Disorder (PHASE2)
- A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy (PHASE2)
- A Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy (PHASE2)
- Study to Evaluate Efficacy, Safety and Tolerability of JNJ-42847922 in Participants With Insomnia Disorder Without Psychiatric Comorbidity (PHASE2)
- A Study to Investigate the Antidepressant Mechanism-of-action of JNJ-42847922 in Participants With Major Depressive Disorder (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Matching placebo to Seltorexant CI brief — competitive landscape report
- Matching placebo to Seltorexant updates RSS · CI watch RSS
- Janssen Research & Development, LLC portfolio CI
Frequently asked questions about Matching placebo to Seltorexant
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Related
- Manufacturer: Janssen Research & Development, LLC — full pipeline
- Therapeutic area: All drugs in Neurology
- Indication: Drugs for Matching placebo control for Seltorexant clinical trials (not a therapeutic agent)
- Compare: Matching placebo to Seltorexant vs similar drugs
- Pricing: Matching placebo to Seltorexant cost, discount & access