Insulin combination therapy

This page covers all Insulin combination therapy drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Insulin receptor, Insulin receptor (detemir and aspart); AMPK and mitochondrial glycerophosphate dehydrogenase (metformin), Amylin receptor (pramlintide component); Insulin receptor (insulin component).

Targets

Insulin receptor · Insulin receptor (detemir and aspart); AMPK and mitochondrial glycerophosphate dehydrogenase (metformin) · Amylin receptor (pramlintide component); Insulin receptor (insulin component)

Marketed (17)

• NPH/Reg · Tehran University of Medical Sciences · Diabetes
  NPH/Reg is a combination insulin therapy that provides both intermediate-acting (NPH) and rapid-acting (Regular) insulin to control blood glucose levels.
• Insulin Lispro Mix25 · Eli Lilly and Company · Diabetes
  Insulin Lispro Mix25 is a rapid-acting insulin analog combined with intermediate-acting insulin that binds to insulin receptors to facilitate glucose uptake and utilization in cells.
• Lispro Low Mix · Eli Lilly and Company · Diabetes
  Lispro Low Mix is a fixed-ratio combination of rapid-acting insulin lispro and intermediate-acting insulin lispro protamine suspension that mimics physiologic insulin secretion by providing both mealtime and basal insulin coverage.
• Detemir insulin, Aspart insulin, Metformin · University Hospital, Toulouse · Endocrinology / Diabetes
  This combination therapy uses two insulin types (long-acting detemir and rapid-acting aspart) plus metformin to lower blood glucose by increasing insulin signaling and reducing hepatic glucose production.
• Novolin 70/30 · Wockhardt · Diabetes
  Novolin 70/30 is a fixed-ratio insulin combination that replaces or supplements the body's natural insulin to regulate blood glucose levels.
• NPH and regular insulin · Riverside University Health System Medical Center · Diabetes
  NPH and regular insulin work together to replace or supplement the body's natural insulin, allowing cells to take up glucose and lowering blood sugar levels.
• Humulin N plus Humulin R · Université NAZI BONI · Diabetes
  This combination of intermediate-acting (NPH) and rapid-acting insulin provides basal and prandial glucose control by facilitating cellular glucose uptake and metabolism.
• Insulin lispro low mix · Eli Lilly and Company · Diabetes
  Insulin lispro low mix is a combination of rapid-acting insulin lispro and intermediate-acting insulin lispro protamine suspension that mimics physiological insulin secretion by providing both mealtime and basal insulin coverage.
• Lispro mix 75/25 · Eli Lilly and Company · Diabetes
  Lispro mix 75/25 is a combination insulin that provides rapid-acting insulin coverage for mealtime glucose spikes plus intermediate-acting basal insulin for baseline glucose control.
• Lispro Mixture Therapy · Eli Lilly and Company · Diabetes
  Lispro Mixture is a combination of rapid-acting insulin lispro and intermediate-acting insulin lispro protamine suspension that mimics physiologic insulin secretion by providing both mealtime and basal insulin coverage.
• Pramlintide + Insulin · Montefiore Medical Center · Diabetes
  Pramlintide slows gastric emptying and suppresses glucagon secretion, while insulin lowers blood glucose, together improving postprandial glucose control in diabetes.
• Humalog Mix 75/25 · Biodel · Diabetes
  Humalog Mix 75/25 is a combination insulin product that provides both rapid-acting and intermediate-acting insulin to control blood glucose levels in diabetes.
• premix insulin · Shanghai 6th People's Hospital · Diabetes
  Premix insulin is a combination of rapid-acting and intermediate-acting insulin that replaces or supplements the body's natural insulin to regulate blood glucose levels.
• Premixed insulin · Peking University People's Hospital · Diabetes
  Premixed insulin combines rapid-acting and intermediate-acting insulin to provide both immediate and sustained blood glucose control.
• Lispro Mid Mix · Eli Lilly and Company · Diabetes
  Lispro Mid Mix is a fixed-ratio combination of rapid-acting insulin lispro and intermediate-acting insulin isophane that mimics the body's natural insulin secretion pattern by providing both immediate and sustained glucose control.
• Lispro Mix 50/50 · Eli Lilly and Company · Diabetes
  Lispro Mix 50/50 is a combination insulin that provides both rapid-acting and intermediate-acting insulin to control blood glucose in diabetes.
• NPH/Regular 70/30 mix · Dennis G. Karounos, M.D. · Diabetes
  This insulin mixture combines intermediate-acting NPH insulin with rapid-acting regular insulin to provide both basal and mealtime glucose control in diabetes.

Phase 3 pipeline (4)

• Humalog Mix 50 · Eli Lilly and Company · Diabetes
  Humalog Mix 50 is a combination insulin therapy that provides both rapid-acting and intermediate-acting insulin to control blood glucose levels in diabetes.
• IDegAsp · Sanofi · Diabetes
  IDegAsp is a fixed-ratio combination insulin that provides both long-acting basal insulin coverage and rapid-acting mealtime insulin in a single injection.
• Humulin Insulin Mixtard · Ain Shams University · Diabetes
  Humulin Insulin Mixtard is a fixed combination of rapid-acting and intermediate-acting insulin that replaces or supplements endogenous insulin to regulate blood glucose levels.
• Insulin Glargine - Insulin Aspart · Hospital Universitario San Ignacio · Diabetes
  This combination of long-acting basal insulin (glargine) and rapid-acting mealtime insulin (aspart) works together to regulate blood glucose by replacing the body's natural insulin secretion pattern.

Patent intelligence

• insulin combination patent landscape — aggregated cliff calendar, attackable patents, originator estates