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Humulin N plus Humulin R
This combination of intermediate-acting (NPH) and rapid-acting insulin provides basal and prandial glucose control by facilitating cellular glucose uptake and metabolism.
This combination of intermediate-acting (NPH) and rapid-acting insulin provides basal and prandial glucose control by facilitating cellular glucose uptake and metabolism. Used for Type 1 diabetes mellitus, Type 2 diabetes mellitus.
At a glance
| Generic name | Humulin N plus Humulin R |
|---|---|
| Sponsor | Université NAZI BONI |
| Drug class | Insulin combination therapy |
| Target | Insulin receptor |
| Modality | Small molecule |
| Therapeutic area | Diabetes |
| Phase | FDA-approved |
Mechanism of action
Humulin N is an isophane (NPH) insulin suspension that provides long-acting basal insulin coverage over 24 hours. Humulin R is a regular (short-acting) insulin that provides rapid postprandial glucose control. Together, they mimic physiologic insulin secretion patterns in diabetic patients.
Approved indications
- Type 1 diabetes mellitus
- Type 2 diabetes mellitus
Common side effects
- Hypoglycemia
- Injection site reactions
- Lipodystrophy
- Weight gain
Key clinical trials
- DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes (PHASE4)
- Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin (PHASE4)
- Safety of Topical Insulin Drops for Open-angle Glaucoma (PHASE1)
- Comparison Between Oxycodone and Pregabalin as Preemptive Analgesia (PHASE2, PHASE3)
- Immunosafety Study of Recombinant Human Insulins in Type 1 Diabetics (PHASE3)
- Humalog® Mix50/50(tm) as a Treatment for Gestational Diabetes (PHASE4)
- A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to "Standard of Care" Basal Insulins in Insulin Naïve Patients Initiating Insulin (PHASE4)
- A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to "Standard of Care" Basal Insulin in Patients Already Using Basal Insulin (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Humulin N plus Humulin R CI brief — competitive landscape report
- Humulin N plus Humulin R updates RSS · CI watch RSS
- Université NAZI BONI portfolio CI