{"id":"humulin-n-plus-humulin-r","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypoglycemia"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Lipodystrophy"},{"rate":null,"effect":"Weight gain"}]},"_chembl":{"chemblId":"CHEMBL1201631","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Humulin N is an isophane (NPH) insulin suspension that provides long-acting basal insulin coverage over 24 hours. Humulin R is a regular (short-acting) insulin that provides rapid postprandial glucose control. Together, they mimic physiologic insulin secretion patterns in diabetic patients.","oneSentence":"This combination of intermediate-acting (NPH) and rapid-acting insulin provides basal and prandial glucose control by facilitating cellular glucose uptake and metabolism.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:23:16.805Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 1 diabetes mellitus"},{"name":"Type 2 diabetes mellitus"}]},"trialDetails":[{"nctId":"NCT06445946","phase":"PHASE4","title":"DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes","status":"RECRUITING","sponsor":"Ohio State University","startDate":"2024-08-01","conditions":"Gestational Diabetes Mellitus, Pregnancy, High Risk","enrollment":1572},{"nctId":"NCT05768191","phase":"PHASE4","title":"Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin","status":"COMPLETED","sponsor":"Université NAZI BONI","startDate":"2023-06-15","conditions":"Type 1 Diabetes","enrollment":22},{"nctId":"NCT04118920","phase":"PHASE1","title":"Safety of Topical Insulin Drops for Open-angle Glaucoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2023-03-27","conditions":"Glaucoma","enrollment":18},{"nctId":"NCT05389813","phase":"PHASE2, PHASE3","title":"Comparison Between Oxycodone and Pregabalin as Preemptive Analgesia","status":"UNKNOWN","sponsor":"An-Najah National University","startDate":"2021-08-15","conditions":"Anesthesia","enrollment":150},{"nctId":"NCT01308437","phase":"PHASE3","title":"Immunosafety Study of Recombinant Human Insulins in Type 1 Diabetics","status":"TERMINATED","sponsor":"Wockhardt","startDate":"2011-03","conditions":"Type I Diabetes","enrollment":134},{"nctId":"NCT01613807","phase":"PHASE4","title":"Humalog® Mix50/50(tm) as a Treatment for Gestational Diabetes","status":"COMPLETED","sponsor":"Sansum Diabetes Research Institute","startDate":"2008-10","conditions":"Gestational Diabetes Mellitus","enrollment":40},{"nctId":"NCT02967224","phase":"PHASE4","title":"A \"Real World\" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to \"Standard of Care\" Basal Insulins in Insulin Naïve Patients Initiating Insulin","status":"COMPLETED","sponsor":"Sanofi","startDate":"2015-11-05","conditions":"Diabetes Mellitus, Type 2","enrollment":705},{"nctId":"NCT02967211","phase":"PHASE4","title":"A \"Real World\" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to \"Standard of Care\" Basal Insulin in Patients Already Using Basal Insulin","status":"COMPLETED","sponsor":"Sanofi","startDate":"2015-12-21","conditions":"Diabetes Mellitus, Type 2","enrollment":609},{"nctId":"NCT03511521","phase":"PHASE4","title":"Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia","status":"TERMINATED","sponsor":"Northwestern University","startDate":"2018-03-27","conditions":"Hyperglycemia Steroid-induced, Insulin Resistance, Diabetes","enrollment":3},{"nctId":"NCT01854723","phase":"PHASE4","title":"Comparison Study of Insulin Glargine and NPH Insulin","status":"WITHDRAWN","sponsor":"Providence Health & Services","startDate":"2013-04","conditions":"Diabetes","enrollment":""},{"nctId":"NCT03507829","phase":"PHASE3","title":"Insulin Therapy for the Prevention of New Onset Diabetes After Transplantation Prospective Study in Non-Diabetic De Novo Kidney Transplant Recipients","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2012-11-21","conditions":"Hyperglycemia","enrollment":263},{"nctId":"NCT01680185","phase":"PHASE3","title":"Sensor-Augmented Insulin-Pump Therapy in New-onset Diabetes After Transplantation","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2012-08","conditions":"Hyperglycemia","enrollment":85},{"nctId":"NCT01662921","phase":"PHASE2","title":"Comparator Trial Using Insulin Glulisine vs. Insulin Lispro for Treatment of Gestational Diabetes","status":"COMPLETED","sponsor":"Sansum Diabetes Research Institute","startDate":"2013-04","conditions":"Diabetes During Pregnancy","enrollment":17},{"nctId":"NCT02451917","phase":"PHASE4","title":"Glargine Versus NPH in Patients With Chronic Kidney Disease","status":"COMPLETED","sponsor":"University of Sao Paulo General Hospital","startDate":"2013-12","conditions":"Type 2 Diabetes Mellitus, Chronic Kidney Disease","enrollment":34},{"nctId":"NCT00835861","phase":"PHASE2","title":"Effectiveness of Metformin Compared to Insulin in Pregnant Women With Mild Preexisting or Early Gestational Diabetes","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2008-08","conditions":"Non Insulin Dependent Diabetes, Pregnancy","enrollment":31},{"nctId":"NCT00593255","phase":"PHASE4","title":"Efficacy and Safety of Insulin Aspart in Subjects With Type 1 or Type 2 Diabetes","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2004-07","conditions":"Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2","enrollment":220},{"nctId":"NCT00000620","phase":"PHASE3","title":"Action to Control Cardiovascular Risk in Diabetes (ACCORD)","status":"COMPLETED","sponsor":"National Heart, Lung, and Blood Institute (NHLBI)","startDate":"1999-09","conditions":"Atherosclerosis, Cardiovascular Diseases, Hypercholesterolemia","enrollment":10251},{"nctId":"NCT02222623","phase":"NA","title":"The Inova Type 2 Diabetes Mellitus Study","status":"WITHDRAWN","sponsor":"Inova Health Care Services","startDate":"2015-04","conditions":"Diabetes, Type 2","enrollment":""},{"nctId":"NCT01588639","phase":"","title":"To Evaluate Clinical Outcome and Injection Compliance of Scilin","status":"COMPLETED","sponsor":"Bayer","startDate":"2012-08","conditions":"Diabetes Mellitus, Type 2","enrollment":2683},{"nctId":"NCT00522210","phase":"NA","title":"Comparison of a Twice Daily Versus a Three Times Daily Insulin Regimen in Children With Type 1 Diabetes","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2008-03","conditions":"Type 1 Diabetes","enrollment":18},{"nctId":"NCT00590226","phase":"PHASE4","title":"Insulin Detemir Versus NPH Insulin In Hospitalized Patients With Diabetes","status":"COMPLETED","sponsor":"Emory University","startDate":"2006-12","conditions":"Type 2 Diabetes","enrollment":130},{"nctId":"NCT01833559","phase":"NA","title":"Impact of Blood Glucose at the First Trimester of Pregnant Women With Gestational Diabetes on Maternal and Fetal Outcomes and Metabolic Disorders: a Multi-central Prospective Cohort Study","status":"UNKNOWN","sponsor":"First Affiliated Hospital, Sun Yat-Sen University","startDate":"2012-06","conditions":"Gestational Diabetes","enrollment":3},{"nctId":"NCT01270191","phase":"PHASE4","title":"The Effects of Short-Term Exenatide Therapy in Newly Diagnosed Type 2 Diabetic Patients","status":"UNKNOWN","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2010-11","conditions":"Type 2 Diabetes","enrollment":160},{"nctId":"NCT01717911","phase":"PHASE4","title":"ß-Cell Function and Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients With Moderate Hyperglycemia","status":"UNKNOWN","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2010-09","conditions":"Type 2 Diabetes","enrollment":160},{"nctId":"NCT00147836","phase":"NA","title":"Evaluation of the Effects of Different Interventions on Glycemic Control in Newly-Diagnosed Type 2 Diabetic Patients","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2004-09","conditions":"Type 2 Diabetes Mellitus","enrollment":436}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Humulin N plus Humulin R","genericName":"Humulin N plus Humulin R","companyName":"Université NAZI BONI","companyId":"universit-nazi-boni","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination of intermediate-acting (NPH) and rapid-acting insulin provides basal and prandial glucose control by facilitating cellular glucose uptake and metabolism. Used for Type 1 diabetes mellitus, Type 2 diabetes mellitus.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}