What are Fibrin sealant drugs?

Fibrin sealant drugs are pharmacologic agents that share a common mechanism (typically targeting Fibrinogen (substrate for thrombin-catalyzed polymerization)). 2 are currently marketed, with 3 more in clinical development.

What are the marketed Fibrin sealant drugs?

Marketed Fibrin sealant drugs include Tisseel Fibrin Sealant, Fibrin Sealant (Artiss).

Fibrin sealant

2 marketed 3 in Phase 3

This page covers all Fibrin sealant drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Fibrinogen (substrate for thrombin-catalyzed polymerization), Fibrinogen; thrombin substrate, Fibrinogen; Thrombin substrate.

Targets

Fibrinogen (substrate for thrombin-catalyzed polymerization) · Fibrinogen; thrombin substrate · Fibrinogen; Thrombin substrate · Fibrinogen and thrombin (coagulation cascade)

Marketed (2)

Tisseel Fibrin Sealant · Massachusetts General Hospital · Surgery/Hemostasis
Tisseel is a fibrin sealant that mimics the final step of the coagulation cascade to form a stable clot and seal tissue surfaces.
Fibrin Sealant (Artiss) · Nguyen, Davis B., M.D. · Surgery/Hemostasis
Fibrin Sealant (Artiss) forms a fibrin clot by combining thrombin and fibrinogen to achieve hemostasis and tissue adhesion.

Phase 3 pipeline (3)

TISSEEL Lyo · Baxter Healthcare Corporation · Surgical Hemostasis
TISSEEL Lyo is a fibrin sealant used to control bleeding.
TISSEEL VH fibrin sealant · Baxter Healthcare Corporation · Surgery/Hemostasis
TISSEEL VH is a fibrin sealant that mimics the final step of the coagulation cascade to form a stable fibrin clot for hemostasis and tissue sealing.
Fibrinogen human (TachoSil) · Nycomed · Surgery/Hemostasis
TachoSil is a fibrin sealant that provides hemostasis by combining human fibrinogen and thrombin to form a stable fibrin clot at the surgical site.