Last reviewed 2026-04-23 · How we verify

Fibrinogen human (TachoSil)

TachoSil is a fibrin sealant that provides hemostasis by combining human fibrinogen and thrombin to form a stable fibrin clot at the surgical site.

TachoSil is a fibrin sealant that provides hemostasis by combining human fibrinogen and thrombin to form a stable fibrin clot at the surgical site. Used for Hemostasis in surgical procedures, Tissue adhesion in cardiac, vascular, and general surgery.

At a glance

Mechanism of action

TachoSil consists of a collagen patch coated with human fibrinogen and human thrombin. When applied to bleeding surfaces, the thrombin activates the fibrinogen to form fibrin, which polymerizes and creates a mechanical seal. This provides rapid hemostasis and adhesion at surgical sites, reducing bleeding and promoting tissue adhesion.

Approved indications

• Hemostasis in surgical procedures
• Tissue adhesion in cardiac, vascular, and general surgery

Common side effects

• Infection at surgical site
• Seroma formation
• Hematoma
• Allergic reaction

Key clinical trials

• GATT-Patch Versus TachoSil in Liver Surgery (NA)
• NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery (NA)
• A Study Evaluating the Safety and Preliminary Efficacy of sFilm-FS in Controlling Parenchymal Bleeding During Elective Hepatic Surgery (PHASE1, PHASE2)
• Assessment of Long-term Effects of Tachosil
• Neoveil® Versus TachoSil® for the Treatment of Pulmonary Air Leaks Following Lung Operation (NA)
• Observational Pilot Study With TachoSil as a Ventricular Sealant
• RollOut -Pre-Rolled TachoSil in Laparoscopic Utilisation. A Non-Interventional Study
• Impact of a Surgical Sealing Patch on Lymphatic Drainage After ALND for Breast Cancer (PHASE3)

Primary sources

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